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Figure 1 | BMC Immunology

Figure 1

From: A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice

Figure 1

Generation of mTOR kinase-dead knock-in mice. Schematic map of the wild-type mTOR gene locus, targeted allele before and after Cre recombination. Exons are represented by white boxes. LoxP sites are shown as black boxes. Positions of Southern blot probes, PCR primers, and restriction enzyme sites are indicated. PGK-Neo, neomycin resistance gene. Asterisk shows D2338A mutation in exon 50.

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