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Figure 1 | BMC Immunology

Figure 1

From: Phenotype, functions and fate of adoptively transferred tumor draining lymphocytes activated ex vivo in mice with an aggressive weakly immunogenic mammary carcinoma

Figure 1

Adoptive transfer of bryostatin and ionomycin activated tumor DLN lymphocytes induces regression of 10 day 4T1 tumors. Mice with established 9 day tumors either were untreated or were treated with CYP (100 mg/kg i.p. on day 9), alone, or CYP followed by adoptive transfer of 10 × 106 4T1 DLN lymphocytes (on day 10) which had been activated with B/I and expanded in culture. Mean tumor areas ± SE are charted over time versus days after tumor inoculation. Treatment with CYP + B/I activated lymphocytes induced complete tumor regressions in 100% of the mice. CYP treatment alone slowed tumor growth only temporarily. Numbers to the right indicate the number of mice with complete tumor regression per total number of mice in each group. The CYP + AIT group was significantly different from the Nil and CYP groups [F(2,17) = 21.8328, P < 0.0001].

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BMC Immunology

ISSN: 1471-2172

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