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Figure 2 | BMC Immunology

Figure 2

From: Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets

Figure 2

Expression of chemokine receptors and chemotaxis of PD-1-expressing T cells. (A) Expression of CXCR5, CCR7 and CXCR4. (B) Chemotaxis to respective chemokine ligands, CXCL13, CCL19 and CXCL12. (C) Expression of CXCL12 in the tonsil follicular area. % Cells expressing indicated chemokine receptors among each group of cells are shown in panel A. %Net migration in panel B indicates specific cell migration levels after subtraction of the background migration occurring in the control medium. The inset in panel C is the image obtained with an anti-PD-1 antibody and an isotype control antibody. Combined (A) or representative data (A, B, and C) of at least 3 independent experiments are shown. "*" and "**"indicate significant differences from naïve T cells and PD-1++ cells respectively. "MFI" stands for mean fluorescence intensity.

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