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Figure 4 | BMC Immunology

Figure 4

From: Alteration of DSS-mediated immune cell redistribution in murine colitis by oral colostral immunoglobulin

Figure 4

Colonic infiltration of prophylactically-fed, DSS-exposed mice and untreated control without intervention at day 15. The indicated therapeutics (sIgA, IgG, and BC) were applied parallel to DSS treatment. The untreated group represents healthy animals without any intervention. A: Immunohistochemical staining of a) CD11c+ mature dendritic cells or b) γδTCR+ T-cells in the colon of DSS-exposed mice compared to untreated, healthy controls. Representative images are shown in 200-fold magnification. B: Impact of prophylactic sIgA on cell distribution in lymph nodes and spleen at day 15. The indicated therapeutics (sIgA, IgG, and BC) were applied parallel to DSS treatment. The untreated group represents healthy animals without any intervention. Values are given as percent CD3+CD4+(A), γδTCR+(B), or CD11c+CD83+(C) positive cells of 10,000 measured events and given as mean ± SD. n = 6-8 (Untreated), n = 6 (BC, sIgA), and n = 5 (IgG) mice. *P < 0.05 vs. untreated, Mann Whitney U-test.Values are means ± SD of n = 6 (Untreated, BC, IgA) and n = 5 (IgG) mice.* P < 0.01 vs. untreated, +P < 0.05 vs. IgG, Mann Whitney U-test.

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