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Table 3 Genotype frequencies of STAT6 single nucleotide polymorphisms (SNPs) in HCV-1 and HCV-2 infected patients receiving PEG-IFNα-RBV therapy with and without a SVR in a Chinese population in Taiwan

From: The impact of polymorphisms in STAT6 on treatment outcome in HCV infected Taiwanese Chinese

HCV-1

HCV-2

SNP ID

SVR (+)

SVR (−)

P

OR (95% CI)

SNP ID

SVR (+)

SVR (−)

P

OR (95% CI)

 

N (%)

N (%)

   

N (%)

N (%)

  

rs1059513

rs1059513

A/A

131 (80.4)

93 (91.2)

 

0.40 (0.18, 0.87)

A/A

155 (87.1)

15 (88.2)

 

0.90 (0.19, 4.19)

A/G

32 (19.6)

9 (8.8)

0.0179*

1

A/G

23 (12.9)

2 (11.8)

0.8916

1

G/G

0 (0.0)

0 (0.0)

-

-

G/G

0 (0.0)

0 (0.0)

-

-

A/A + A/G

163 (100.0)

102 (100.0)

-

-

A/A + A/G

178 (100.0)

17 (100.0)

-

-

rs703817 a

rs703817

A/A

11 (6.7)

9 (8.9)

 

0.61 (0.24, 1.58)

A/A

11 (6.2)

0 (0.0)

 

-

A/G

58 (35.6)

45 (44.6)

 

0.64 (0.38, 1.09)

A/G

71 (39.9)

5 (29.4)

 

1.78 (0.60, 5.27)

G/G

94 (57.7)

47 (46.5)

0.2103

1

G/G

96 (53.9)

12 (70.6)

0.3223

1

A/A + A/G

69 (42.3)

54 (53.5)

0.0780

0.64 (0.39, 1.05)

A/A + A/G

82 (46.1)

5 (29.4)

0.1869

2.05 (0.69, 6.06)

rs324015 a

rs324015

A/A

34 (20.9)

20 (19.8)

 

1.05 (0.52, 2.12)

A/A

39 (21.9)

6 (35.3)

 

0.43 (0.10, 1.85)

A/G

77 (47.2)

49 (48.5)

 

0.97 (0.55, 1.71)

A/G

94 (52.8)

8 (47.1)

 

0.78 (0.20, 3.09)

G/G

52 (31.9)

32 (31.7)

0.9723

1

G/G

45 (25.3)

3 (17.6)

0.4339

1

A/A + A/G

111 (68.1)

69 (68.3)

0.9704

0.99 (0.58, 1.69)

A/A + A/G

133 (74.7)

14 (82.4)

0.4851

0.63 (0.17, 2.31)

rs3024974

rs3024974 b

C/C

105 (64.4)

61 (59.8)

 

0.34 (0.07, 1.62)

C/C

113 (63.9)

11 (64.7)

 

2.05 (0.22, 19.19)

C/T

48 (29.5)

39 (38.2)

 

0.25 (0.05, 1.19)

C/T

59 (33.3)

5 (29.4)

 

2.36 (0.23, 24.33)

T/T

10 (6.1)

2 (2.0)

0.1285

1

T/T

5 (2.8)

1 (5.9)

0.7623

1

C/C + C/T

153 (93.9)

100 (98.0)

0.1118

0.31 (0.07, 1.43)

C/C + C/T

172 (97.2)

16 (94.1)

0.4867

2.15 (0.24, 19.55)

  1. a Contains 1 missing data point in the SVR (−) group.
  2. b Contains 1 missing data point in the SVR (+) group.
  3. Abbreviations: SNP single nucleotide polymorphism, SVR sustained virological response, OR odds ratio, CI Confidence interval.
  4. Genotype frequencies were determined by χ2 test using 2 × 3 or 2 × 2 tables as appropriate. Odds ratios and 95% CI per genotype were estimated by unconditional logistic regression. P values less than 0.05 were considered statistically significant, and are denoted with an asterisk.