The impact of polymorphisms in STAT6 on treatment outcome in HCV infected Taiwanese Chinese

BMC Immunology

Table 6 Distribution of haplotype frequencies from SNPs of STAT6 gene in 265 HCV-1 infected populations and their associations with SVR

Haplotypes^*	SVR (+) (%)	SVR (−) (%)	P Global^†	P individual^§	OR (95% CI)
AGGT	66 (20.3)	40 (19.6)	0.2126	0.8583	1.04 (0.67, 1.61)
AGGC	4 (1.2)	2 (1.0)		0.7940	1.25 (0.23, 6.91)
AGAT	2 (0.6)	3 (1.5)		0.3206	0.41 (0.07, 2.50)
AGAC	144 (44.2)	87 (42.6)		0.7305	1.06 (0.75, 1.51)
AAGC	78 (23.9)	63 (30.9)		0.0778	0.70 (0.48, 1.04)
GGGC	31 (9.5)	9 (4.4)		0.0306*	2.28 (1.06, 4.89)
GGAC	1 (0.3)	0 (0.0)		0.4285	-

^*Order of SNPs comprising the STAT6 haplotypes: rs1059513, rs703817, rs324015 and rs3024974. The haplotypes were identified by the Bayesian statistical method available in the program Phase 2.1.
^† Global test for haplotypes frequency in relation to SVR was determined by χ² test using 2 × 7 contingency tables.
^§ Individual haplotype frequency in relation to SVR was determined by χ² test using 2 × 2 contingency tables. P values less than 0.05 were considered statistically significant, and are denoted with an asterisk. ORs and 95% CI were estimated by unconditional logistic regression model.

ISSN: 1471-2172