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Figure 8 | BMC Immunology

Figure 8

From: Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection

Figure 8

Effect of lactobacilli on the production of cytokines induced by respiratory syncytial virus (RSV) infection. Effect of viable (Lr05) or heat-killed (HkLr05) Lactobacillus rhamnosus CRL1505 and viable (Lr06) or heat-killed (HkLr06) L. rhamnosus CRL1506 nasal administration on the tumor necrosis factor (TNF)-α, interferon (IFN)-α, IFN-β, IFN-γ, interleukin (IL)-6 and IL-10 concentrations in broncho-alveolar lavages (BAL). Lr05, Lr06, HkLr05 or HkLr06 were nasally administered to different groups of mice for 2 consecutive days at a dose of 108 cells/mouse/day. After lactobacilli treatment, mice were nasally challenged with RSV and BAL cytokines were studied 12 (TNF-α, IFN-β and IL-6) or 48 (IFN-γ and IL-10) hours after the challenge. The results represent data from three independent experiments. Different letters indicate significant differences (P < 0.05).

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