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Figure 1 | BMC Immunology

Figure 1

From: Lupus-like oral mucosal lesions in mercury-induced autoimmune response in Brown Norway rats

Figure 1

Immunohistochemical staging of infiltrating mononuclear cells in the tongue of the mercury-treated rats. A-D: The tongue specimens from the control rats show MHC class II+ cells distributed sparsely to both the lamina propria and surface epithelium (A). The number of MHC class II+ cells increases continuously as phase progress (B-D). E-H: A few ED1+ cells are in the lamina propria of normal tongue (E). During progression of phases, the number of ED1+ cells is increased in upper lamina propria (F-H). I-L: A small number of CD5+ T cells are distributed in the lamina propria of tongue specimens from phases I and II as well as the control rats (I-K). In phase III specimens, focal accumulations of CD5+ T cells are present in both the lamina propria and surface epithelium (L). M-P: No obvious changes are noted in hematoxylin-eosin (HE)-stained tongue sections taken from thec ontrol, phase I and phase II rats (M-O). Infiltrates of mononuclear cells are observed in the lamina propria of the oral mucosa in phase III specimens (P). Bar= 100μm.

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