Table 2 Genes showing altered (>2 fold) gene expression in tissue lesions of CL compared to human normal skin (Control)
Gene name | Gene accession no. | Major function | Relative mRNA expression (CL/Control) |
|---|---|---|---|
Cytokines & Chemokines | |||
Interleukin (IL)-8 | Y00787 | Chemo-attractant and inflammatory response | 22.51 |
Interferon (IFN)-γ | X01992 | Immunoregulatory and anti-tumor properties, activator of macrophages | 15.32 |
IL-12β | M65290 | Inducer of IFN-γ, differentiation of both Th1 and Th2 cells | 14.87 |
Monokine induced by gamma interferon (CXCL9) | X72755 | T cell trafficking | 12.47 |
Tumor necrosis factor (TNF)-α | X01394 | Proinflammatory cytokine, cell proliferation, differentiation, apoptosis | 10.81 |
C-Chemokine ligand (CCL4) or (MIP-1β) | J04130 | Chemo-attractant of monocytes/macrophages | 9.65 |
Granulocyte macrophage colony stimulating factor (GMCSF) | M11220 | Production, differentiation, and function of granulocytes and macrophage | 6.16 |
IL-13 | L06801 | Inhibition of production of pro-inflammatory cytokines and chemokines | 5.50 |
CCL-3 or (MIP-1α) | M23452 | Inflammatory responses | 4.38 |
Transforming growth factor (TGF)-α | K03222 | Cell proliferation, differentiation and development | 4.15 |
IL-10 | M57627 | Pleiotropic effects in immunoregulation and inflammation | 3.92 |
CXCL-5 | X78686 | Inflammatory chemokine involved in neutrophil activation | 3.81 |
IL-17 | U32659 | Proinflammatory cytokine, high levels are associated with several chronic inflammatory diseases | 3.77 |
IL-1β | K02770 | Mediator of the inflammatory response, involved in cell proliferation, differentiation, and apoptosis | 3.75 |
IL-6 | X04602 | Functions in inflammation and the maturation of B cells | 3.59 |
CXCL2 | X53799 | Chemokine with inflammatory activity | 3.23 |
IL-4 | M13982 | Pleiotropic cytokine, regulator of NO synthesis | 2.62 |
CCL-2 or (MCP-1) | M24545 | Chemokine activity, immunoregulatory and inflammatory processes | 2.31 |
TGF-β | X02812 | Embryogenesis and cell differentiation | 2.01 |
IL-3 | M14743 | Cell growth, differentiation, apoptosis | 0.47 |
Pleiotrophin | M57399 | Growth factor, heparin binding activity | 0.25 |
Receptors | |||
CCR-2 | U03905 | Monocyte infiltration, in inflammatory diseases | 10.40 |
IL-10Rα | U00672 | Inhibits the synthesis of proinflammatory cytokines, promote survival of progenitor myeloid cells | 8.63 |
IL-12Rβ | U03187 | Receptor for IL-12 | 6.17 |
TRAILR-1 | U90875 | Transduces cell death signal and induces cell apoptosis | 4.91 |
IL-9R | M84747 | The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins | 4.71 |
CD40 | L07414 | T cell-dependent immunoglobulin class switching, memory B cell development | 4.58 |
Fas | M67454 | physiological regulation of programmed cell death | 4.21 |
IL-6R | X12830 | Regulates cell growth and differentiation and plays an important role in the immune response | 4.16 |
IL4R | X52425 | Interleukins & Interferons receptors | 3.91 |
IL-8Rα | M68932 | Interleukins & Interferons receptors | 3.33 |
IL-2Rα or CD25 | X01057 | Transduction of mitogenic signals from IL-2 | 3.00 |
IL-2Rγ | D11086 | Signaling initiation and T cell proliferation | 2.38 |
Complement component 5 receptor 1 | M62505 | Defense response to bacteria | 0.45 |
IL-3Rα | M74782 | Interleukins & Interferons receptors | 0.43 |
Others | |||
S100 calcium binding protein A8 (calgranulin A) | X06234 | Cell cycle progression and differentiation | 7.18 |
Interferon regulatory factor 8 (IRF-8) | M91196 | Transcription Activators & Repressors | 6.16 |
S100 calcium binding protein A9 (calgranulin B) | X06233 | Cell cycle progression and differentiation | 4.28 |
PTK7 protein tyrosine kinase 7 | U33635 | Cell adhesion molecule, intracellular transducers, effectors & modulators | 3.92 |
IRF-1 | X14454 | Transcription activator of genes induced by IFN-α, β, γ and apoptosis | 3.09 |
TEK tyrosine kinase, endothelial | L06139 | TEK signaling pathway critical for endothelial cell-smooth muscle cell communication | 2.78 |
AXL receptor tyrosine kinase | M76125 | Stimulation of cell proliferation and cell aggregation | 2.53 |
RYK receptor-like tyrosine kinase | S59184 | Intracellular transducers, effectors & modulators | 2.29 |
Thrombomodulin | M16552 | Thrombin binding, activation of protein C, | 0.42 |
PDGFA associated protein 1 | U41745 | Fibroblast growth | 0.31 |
Thrombopoietin | L36052 | Megakaryocyte proliferation, maturation and thrombopoiesis | 0.23 |