Figure 2

Time-course of bladder morphological alterations in response to weekly instillations with BCG. Representative photomicrographs of a time-dependent alteration of the mouse bladder secondary to intravesical instillation of BCG. Note, the intense edema observed days 1–7 after the first instillation with BCG (A and B) and the subsequent invasion of inflammatory cells into the submucosa at day 7 (B) and a time-dependent invasion of the detrusor muscle at days 21 (C) and 28 (D-F). Granuloma-like formation is indicated by wavy white lines.