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Figure 2 | BMC Immunology

Figure 2

From: The role of Toll-like receptor-4 in pertussis vaccine-induced immunity

Figure 2

Ptx-, FHA-, and Prn-specific IgG in serum. Tlr4-deficient and control mice were sc injected with 1/5 HD wP, aP, or adjuvant (C), twice before intranasal B. pertussis infection. Two hours before challenge, and three and seven days after challenge blood was taken. Test and positive control sera were tested for Ptx-, FHA-, and Prn-specific IgG. Each symbol represents the serum level of an individual mouse; horizontal lines represent the group average. (#) increased compared to the adjuvant control (same strain and time point; P < 0.001), (+) increased compared to wP-vaccinated mice (same strain and time point; P < 0.001). Non-boxed P-values: compared to the indicated group (same strain and time point), boxed P-values: compared to the wild-type strain (same treatment and time point), and stippled-boxed P-values: compared to the pre-challenge level (same strain and treatment). ANOVA followed by Bonferroni post-hoc test. A single representative experiment of 2 is shown.

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