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Figure 8 | BMC Immunology

Figure 8

From: Divergence of canonical danger signals: The genome-level expression patterns of human mononuclear cells subjected to heat shock or lipopolysaccharide

Figure 8

Merge of two top scoring IPA networks derived from the list of 430 genes common to both the downregulated LPS-responsive gene list and the downregulated heat shock-responsive gene list. The merged network is depicted in the context of cellular compartments. This downregulated, common LPS/heat shock-responsive network contains two nodes having a high degree of connectivity to other network genes: B-cell CLL/lymphoma 2 (BCL2) in the cytoplasmic compartment and v-myc myelocytomatosis viral oncogene homolog (MYC) in the nuclear compartment. Gold lines indicate connectivity between the two merged networks. See text for network derivation, and see Additional file 8 for network gene list and Additional file 4 for network legend.

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BMC Immunology

ISSN: 1471-2172

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