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Table 2 Functional annotations associated with the downregulated LPS- and heat shock-responsive genes, respectively.

From: Divergence of canonical danger signals: The genome-level expression patterns of human mononuclear cells subjected to heat shock or lipopolysaccharide

 

LPS

Heat Shock

Pathways

• None signficant

• None significant

Biological process (p value)

• Protein metabolism and modification (6.8E-7)

• Nucleoside, nucleotide and nucleic acid metabolism (1.3E-3)

 

• Amino acid metabolism (5.2E-6)

• mRNA transcription regulation

 

• Other metabolism (1.4E-5)

• (2.7E-3)

 

• Carbohydrate metabolism (1.3E-4)

• mRNA transcription (3.3E-2)

 

• Protein modification (2.2E-4)

 

Molecular function (p value)

• Oxidoreductase (5.0E-7)

• Transferase (1.4E-3)

 

• Dehydrogenase (4.4E-6)

• Transcription factor (1.9E-3)

 

• Synthase and synthetase (3.3E-4)

• Nucleic acid binding (9.5E-3)

 

• Transferase (5.5E-4)

 
 

• Lyase (1.5E-3)

 
  1. Data are based on the PANTHER database using the default parameters in the database and Bonferroni correction for multiple comparisons.