Regional variations in Paneth cell antimicrobial peptide expression along the mouse intestinal tract

BMC Immunology

Table 3 Distribution of antimicrobial peptide expression in different mouse tissues measured by qRT-PCR

	CRS1C	CRS4C	Crypt1	Crypt4	sPLA2	pLys	mLys	GAPDH
tongue	*	*	*	*	*	318	7,090	67,100
trachea	*	359	*	*	*	13,000	317,000	22,100
esophagus	*	*	*	*	*	438	29,900	101,000
cardiac stomach	*	882	*	*	*	*	4,730	16,000
body stomach	*	1,570	*	*	*	*	3,040	43,200
pyloric stomach	166	111	1,530	*	1,920	*	5,640	64,600
caecum	210	240,000	29,100	2,630	10,100	3,830	49,400	162,000
ascending colon	*	262	151	*	2,730	339	34,800	142,000
transcending colon	*	*	*	*	12,600	287	25,200	135,000
descending colon	*	*	*	*	9,680	400	34,000	191,000
rectum	*	*	*	*	7,010	445	89,100	72,300
thymus	1,950	19,100	622	224	*	1,820	265,000	48,300
lung	*	101	*	*	*	245,000	1,050,000	29,800
bone marrow	*	*	*	*	*	*	1,080,000	89,000
skin	*	625	*	*	*	*	542	*
liver	*	205	*	*	*	*	24,800	50,100
salivary gland	*	*	*	*	*	144	13,600	31,300
heart	*	*	*	*	*	152	21,400	202,000
kidney	*	*	*	*	*	*	5,610	190,000
spleen	115	393	*	*	*	179	114,000	38,200

Results are based on pooled tissues from 4–20 FVB mice. Caecum and thymus showed highest expression of cryptdins and CRS peptides. * = <100 copies/10 ng RNA. Three significant digits displayed.

ISSN: 1471-2172