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Figure 6 | BMC Immunology

Figure 6

From: Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic mice

Figure 6

Dexamethasone inhibits hIL-1βP-driven luciferase expression in IL-1β-luc transgenic mice in the LPS and zymosan induced inflammation models. (A) Dexamethasone inhibits LPS-induced hIL-1βP-driven luciferase expression. Male cHS4I-hIL-1βP-Luc mice (n = 3/group) were cotreated with vehicle or dexamethasone (3 mg/kg) during the LPS (3 mg/kg) injection. All the mice were imaged at 0 and 5 h after LPS injection. (B) Quantification of luciferase activity (photons/sec) with the LivingImage software. Data presented were mean ± SE. (C) Dexamethasone inhibits hIL-1βP-driven luciferase expression during zymosan induced acute arthritis. Female cHS4I-hIL-1βP-Luc mice (n = 3/group) were cotreated with vehicle or dexamethasone (50 μg/mouse) during the administration of zymosan (300 μg/mouse). All the mice were imaged at 0 and 4 h after zymosan injection. (D) Quantification of luciferase activity (photons/sec) of the articular region of the acute arthritis mice with the LivingImage software. Data presented were mean ± SE. *** indicate significant differences at p < 0.001. p/s/cm2/sr: photons/sec/cm2/steradian.

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