Figure 7
KLH immunisation + in vivo Bv8. Effect of the in vivo administration of Bv8 250 pmoles/kg on the production of IL-10 (panel A) and IL-4 (panel B) by splenocytes of mice immunised with KLH. Two weeks after immunisation, the splenocytes were cultured in the presence or absence of 80 μg/ml KLH for 72 h. Bv8 was administered at the time of immunisation (KLH + Bv8) or 4 h before splenocyte collection two weeks later (KLH +Bv4 h). Results from one typical experiment involving eight mice/group. Mean values ± SD. *p < 0.05 vs corresponding saline-treated animals.