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Table 4 Signaling pathways significantly upregulated at 28 days post-infection

From: Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes

Pathway Name

Enrichment ratio1

Adjusted p value2

Amino Acid Metabolism

16.26

7.79e-15

Complement and Coagulation Cascades

21.56

1.66e-12

Adipogenesis

12.17

1.18e-11

Type II interferon signaling (IFN-γ)

17.77

1.18e-11

Chemokine signaling pathway

9.25

1.46e-10

Blood clotting cascade

39.54

2.74e-10

Toll-like receptor signaling pathway

11.04

1.69e-08

Cytokines and inflammatory Response (BioCarta)

12.47

6.10e-07

IL-4 signaling pathway

12.14

6.89e-07

IL-2 Signaling pathway

9.90

3.38e-06

  1. 1Ratio of the number of genes in the gene set to the expected number in the category based on the human database.
  2. 2p value adjusted by the multiple test adjustment.