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Table 2 RSV infections induce airway cytokine release in mice

From: Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection

 

Wild-type

TrifKO

MavsKO

Cytokine (pg/ml BALF)

Mock

RSV

Mock

RSV

Mock

RSV

IL-1β

3.54±1.51

30.11±9.64*

9.62±8.57

25.53±5.33

6.74±3.56

24.55±3.36

IL-1β

66.61±5.52

78.55±6.66*

67.05±6.19

66.16±5.00*

56.88±2.83

49.18±4.06 #

IL-2

7.25±0.32

5.52±0.31*

6.44±0.03

5.91±1.22

5.36±0.35

6.91±0.75

IL-3

29.39±1.54

28.87±0.84

30.50±1.55

28.95±1.47

22.98±2.89

24.37±0.51

IL-4

15.00±0.01

48.12±0.02*

17.21±0.01

32.89±0.01

14.41±0.01

16.33±0.01 #

IL-5

4.15±0.27

20.00±5.42*

5.39±0.63

7.55±1.46 #

4.37±0.15

4.81±0.50 #

IL-6

3.78±0.44

9.63±3.80*

4.19±0.57

9.79±3.16

3.18±0.31

5.55±1.16 #

IL-9

204.10±11.28

233.11±18.25

230.31±37.74

216.01±18.58

181.42±12.58

228.93±19.01

IL-10

61.43±9.92

76.45±22.60

46.08±8.18

166.2±55.5

51.13±8.32

63.33±12.23

IL-12(p40)

8.69±0.17

11.95±1.65*

9.95±0.97

10.99±1.18

6.89±1.06

8.74±0.28 #

IL-12(p70)

11.34±0.98

10.23±1.43

13.14±3.60

14.89±2.85

8.60±2.10

12.01±3.70

IL-13

48.41±2.44

29.61±3.50*

41.84±4.94

26.51±2.15

47.99±2.33

30.31±6.52

IL-15

6.96±1.09

14.25±3.31*

13.46±3.62

9.83±1.89

7.42±2.18

10.83±1.68

IL-17

43.66±5.10

64.17±16.72

37.61±30.20

79.81±13.48

41.34±5.01

55.44±4.68

IFN-γ

12.15±0.76

35.47±11.26*

10.19±1.26

8.24±0.61 #

11.74±5.04

13.22±3.78 #

MCP-1/CCL2

64.57±2.12

85.14±8.23*

67.87±5.15

81.61±7.86

63.22±5.01

69.99±4.82 #

RANTES/CCL5

12.41±0.84

107.32±21.70*

18.02±3.32

128.81±23.27

15.01±0.98

68.32±11.90 #

TNF-α

524.98±41.34

438.88±55.48

602.71±38.15

460.01±84.64

504.18±32.14

448.88±34.48

MIP-1β/CCL3

105.01±1.38

164.72±5.56*

123.02±18.29

132.58±12.77

95.96±4.84

106.61±4.60 #

MIP-1β/CCL4

66.37±2.89

112.91±19.50*

49.59±4.74

103.10±18.43

54.40±10.08

127.45±41.05

MIP-2/CXCL2

10.22±0.56

10.82±2.04

14.86±1.86

13.40±2.47

9.15±0.80

13.00±1.78

Eotaxin/CCL11

5.72±0.55

25.02±5.97*

9.26±2.68

15.37±3.80

5.94±0.50

13.62±3.08

GM-CSF/CSF2

41.63±3.79

45.57±3.25

49.61±3.60

57.88±6.41

37.14±6.15

45.93±2.41

M-CSF/CSF1

24.93±2.08

26.73±2.47

29.13±2.97

28.85±3.79

20.40±1.97

25.94±2.84

LIF

12.37±5.4

70.18±12.33*

11.12±2.12

60.42±10.32

12.91±3.99

72.32±7.69

CTAK/CCL27

231±21.23

430±43.21*

220±18.91

389.1±21.98

198.3±10.99

424.7±34.76

SDF-1α/CXCL12

94.0±10.16

312.2±50.96*

51.1±23.23

77.21±13.11 #

110.21±20.20

296.19±15.07

SCF

711.00±40.15

1713.06±98.19*

721.79±88.95

1392.90±99.41

702.83±76.41

1721.22±70.60

GROα/KC/CXCL1

1.02±0.45

81.35±16.70

1.24±0.16

81.29±23.27

4.35±0.97

48.55±20.84 #

  1. Cytokine levels were determined in BALF from wild-type, Trif KO and Mavs KO mice 3 days post RSV challenge, by multiplex analysis. Values are represented as mean BALF concentration (pg/ml)±S.E.M. Each assay was performed in triplicate, where n = 10 animals/group. Bold numbers denoted by *represents a p value less than 0.05 compared to mock treated mice. #denotes a p value less than 0.05 compared to RSV treated wild-type mice.