From: Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection
 | Wild-type | TrifKO | MavsKO | |||
---|---|---|---|---|---|---|
Cytokine (pg/ml BALF) | Mock | RSV | Mock | RSV | Mock | RSV |
IL-1β | 3.54±1.51 | 30.11±9.64* | 9.62±8.57 | 25.53±5.33 | 6.74±3.56 | 24.55±3.36 |
IL-1β | 66.61±5.52 | 78.55±6.66* | 67.05±6.19 | 66.16±5.00* | 56.88±2.83 | 49.18±4.06 # |
IL-2 | 7.25±0.32 | 5.52±0.31* | 6.44±0.03 | 5.91±1.22 | 5.36±0.35 | 6.91±0.75 |
IL-3 | 29.39±1.54 | 28.87±0.84 | 30.50±1.55 | 28.95±1.47 | 22.98±2.89 | 24.37±0.51 |
IL-4 | 15.00±0.01 | 48.12±0.02* | 17.21±0.01 | 32.89±0.01 | 14.41±0.01 | 16.33±0.01 # |
IL-5 | 4.15±0.27 | 20.00±5.42* | 5.39±0.63 | 7.55±1.46 # | 4.37±0.15 | 4.81±0.50 # |
IL-6 | 3.78±0.44 | 9.63±3.80* | 4.19±0.57 | 9.79±3.16 | 3.18±0.31 | 5.55±1.16 # |
IL-9 | 204.10±11.28 | 233.11±18.25 | 230.31±37.74 | 216.01±18.58 | 181.42±12.58 | 228.93±19.01 |
IL-10 | 61.43±9.92 | 76.45±22.60 | 46.08±8.18 | 166.2±55.5 | 51.13±8.32 | 63.33±12.23 |
IL-12(p40) | 8.69±0.17 | 11.95±1.65* | 9.95±0.97 | 10.99±1.18 | 6.89±1.06 | 8.74±0.28 # |
IL-12(p70) | 11.34±0.98 | 10.23±1.43 | 13.14±3.60 | 14.89±2.85 | 8.60±2.10 | 12.01±3.70 |
IL-13 | 48.41±2.44 | 29.61±3.50* | 41.84±4.94 | 26.51±2.15 | 47.99±2.33 | 30.31±6.52 |
IL-15 | 6.96±1.09 | 14.25±3.31* | 13.46±3.62 | 9.83±1.89 | 7.42±2.18 | 10.83±1.68 |
IL-17 | 43.66±5.10 | 64.17±16.72 | 37.61±30.20 | 79.81±13.48 | 41.34±5.01 | 55.44±4.68 |
IFN-γ | 12.15±0.76 | 35.47±11.26* | 10.19±1.26 | 8.24±0.61 # | 11.74±5.04 | 13.22±3.78 # |
MCP-1/CCL2 | 64.57±2.12 | 85.14±8.23* | 67.87±5.15 | 81.61±7.86 | 63.22±5.01 | 69.99±4.82 # |
RANTES/CCL5 | 12.41±0.84 | 107.32±21.70* | 18.02±3.32 | 128.81±23.27 | 15.01±0.98 | 68.32±11.90 # |
TNF-α | 524.98±41.34 | 438.88±55.48 | 602.71±38.15 | 460.01±84.64 | 504.18±32.14 | 448.88±34.48 |
MIP-1β/CCL3 | 105.01±1.38 | 164.72±5.56* | 123.02±18.29 | 132.58±12.77 | 95.96±4.84 | 106.61±4.60 # |
MIP-1β/CCL4 | 66.37±2.89 | 112.91±19.50* | 49.59±4.74 | 103.10±18.43 | 54.40±10.08 | 127.45±41.05 |
MIP-2/CXCL2 | 10.22±0.56 | 10.82±2.04 | 14.86±1.86 | 13.40±2.47 | 9.15±0.80 | 13.00±1.78 |
Eotaxin/CCL11 | 5.72±0.55 | 25.02±5.97* | 9.26±2.68 | 15.37±3.80 | 5.94±0.50 | 13.62±3.08 |
GM-CSF/CSF2 | 41.63±3.79 | 45.57±3.25 | 49.61±3.60 | 57.88±6.41 | 37.14±6.15 | 45.93±2.41 |
M-CSF/CSF1 | 24.93±2.08 | 26.73±2.47 | 29.13±2.97 | 28.85±3.79 | 20.40±1.97 | 25.94±2.84 |
LIF | 12.37±5.4 | 70.18±12.33* | 11.12±2.12 | 60.42±10.32 | 12.91±3.99 | 72.32±7.69 |
CTAK/CCL27 | 231±21.23 | 430±43.21* | 220±18.91 | 389.1±21.98 | 198.3±10.99 | 424.7±34.76 |
SDF-1α/CXCL12 | 94.0±10.16 | 312.2±50.96* | 51.1±23.23 | 77.21±13.11 # | 110.21±20.20 | 296.19±15.07 |
SCF | 711.00±40.15 | 1713.06±98.19* | 721.79±88.95 | 1392.90±99.41 | 702.83±76.41 | 1721.22±70.60 |
GROα/KC/CXCL1 | 1.02±0.45 | 81.35±16.70 | 1.24±0.16 | 81.29±23.27 | 4.35±0.97 | 48.55±20.84 # |