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Table 3 RSV infections enhance airway cytokine gene expression

From: Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection

 

Wild-type

TrifKO

MavsKO

Cytokine (pg/ml)

Mock

RSV

Mock

RSV

Mock

RSV

IL-4

1.00±0.40

4.67±1.26*

1.26±0.33

3.97±0.53

0.27±0.14

0.23±0.10 #

IL-6

1.00±0.10

4.15±0.14*

1.30±0.33

3.32±0.52

1.81±0.71

1.61±0.57 #

IL-18

1.00±0.19

0.71±0.16

0.64±0.15

0.43±0.03

0.51±0.06

0.60±0.34

IL-22

1.00±0.41

1.19±0.16

0.98±0.07

1.49±0.49

0.54±0.30

0.45±0.08 #

IL-23

1.00±0.41

1.48±0.27

0.75±0.17

1.41±0.20

0.19±0.15

1.03±0.02

IL-27

1.00±0.15

2.00±0.10*

0.98±0.31

1.88±0.39

0.49±0.06

1.63±0.09

CXCL1/KC

1.00±0.12

11.91±0.05*

1.56±0.67

12.04±0.37

0.29±0.11

3.23±0.12 #

MIG/CXCL9

1.00±0.58

160.81±17.67*

3.18±1.10

148.83±16.68

0.23±0.14

29.47±5.42 #

IP10/CXCL10

1.00±0.18

8.07±1.62*

1.78±0.43

9.77±2.51

0.312±0.10

3.59±2.07 #

IP9/CXCL11

1.00±0.12

2.61±0.26*

1.30±0.44

4.38±0.85

0.18±0.16

3.19±1.05

MIF

1.00±0.19

2.40±0.26*

1.09±0.15

0.90±0.41 #

0.93±0.11

0.52±0.40 #

LIF

1.00±0.14

2.71±0.09*

1.16±0.66

1.01±0.27 #

0.99±0.11

2.43±0.13

CTAK/CCL27

1.00±0.28

5.79±0.67*

1.18±0.18

4.23±0.68

0.73±0.18

4.27±0.42

SDF-1α/CXCL12

1.00±0.16

2.67±0.96*

1.28±0.23

1.57±0.51 #

0.51±0.20

2.59±1.07

SCGF-β

1.00±0.22

1.87±0.16*

1.33±0.14

1.88±0.81

0.88±0.26

1.19±0.15

SCF

1.00±0.15

1.60±0.16*

1.09±0.25

1.20±0.41

0.93±0.11

1.82±0.40

TGF-β

1.00±0.16

1.47±0.06

0.84±0.19

1.00±0.43

0.51±0.01

0.62±0.43

MCP-1/CCL2

1.00±0.08

12.39±3.01*

2.38±0.73

20.45±4.31

0.45±0.07

5.13±1.33 #

MIP-1β/CCL3

1.00±0.08

10.17±1.51*

1.68±0.40

13.64±1.51

0.58±0.14

3.37±0.83 #

  1. Cytokine gene expression levels were determined in lung tissue from wild-type, Trif KO and Mavs KO mice 1 days post RSV challenge by qPCR, except CTAK/CCL27 which was examined 5 days post RSV challenge. Values are represented as mean RQ (relative to mock treated animals, using β-Actin as an endogenous control.)±S.E.M. Each assay was performed in triplicate, where n = 10 animals/group. Bold numbers denoted by *represents a p value less than 0.05 compared to mock treated mice. #denotes a p value less than 0.05 compared to RSV treated wild-type mice.