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Table 1 Subnormal serum IgG subclass levels in adults a

From: Serum immunoglobulins in 28 adults with autoimmune sensorineural hearing loss: increased prevalence of subnormal immunoglobulin G1 and immunoglobulin G3

Cohort

Subnormal Ig level (n)b

Prevalence [95% CI]; value of pc

Relative risk [95% CI]; value of pc

28 ASNHL patients

IgG1 (7)

25.0 [11.4, 45.2]; <0.0001

11.5 [4.1, 31.7]; <0.0001

IgG2 (1)

3.6 [0.2, 20.2]; 0.3863

2.5 [0.3, 21.2]; 0.4143

IgG3 (8)

35.7 [9.3, 55.9]; <0.0001

8.7 [3.7, 20.8]; <0.0001

IgG4 (2)

7.1 [1.3, 25.0]; 0.1978

3.0 [0.7, 13.8]; 0.1561

275 healthy controls

IgG1 (6)

2.1 [0.9, 4.9]

-

IgG2 (4)

1.5 [0.5, 3.9]

-

IgG3 (9)

3.3 [1.6, 6.3]

-

IgG4 (7)

2.6 [1.1, 5.4]

-

  1. aReference ranges for serum IgG subclass levels were mean ± 2 SD for age. Controls included: 125 healthy Irish adult blood donors (68 men, 57 women; ages 48 ± 16 (range 22-81 y); 82 healthy English women (mean 57 y; range 22-90 y); and 68 healthy German blood donors (36 men, 32 women; ages 20-61 years) [21]-[23].
  2. bSubnormal serum IgG subclass levels were reported in these control subjects: IgG1 (3 Ireland, 2 England, 1 Germany); IgG2 (2 Ireland, 2 Germany); IgG3 (3 Ireland, 6 Germany); and IgG4 (4 Ireland, 1 England, and 2 Germany) [21]-[23].
  3. cComparisons with 275 controls [21]-[23].