Skip to main content
Figure 1 | BMC Immunology

Figure 1

From: Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis

Figure 1

Chromosomal configurations in the vicinity of the Fcgr2b gene and SLAM locus of congenic mouse lines. (A) Physical mapping was compiled according to the Ensemble Genome Browser (http://www.ensembl.org/). Upper, gross schematic view, and Lower, detailed genomic structure with SSLP markers, and the genes related to the immune system and examined by SNP analysis (Additional file 1: Table S1 and Additional file 1: Figure S1). Scale bar =1 Mbp. Thick horizontal bars below the map indicate 129 strain-derived intervals, and the flanking, thin broken lines denote intervals unidentified for the B6 or 129 strain. Other areas not shown were derived from B6. The RIIB−/−TACONIC line had a 129-derived interval from D1Mit34 to D1Mit150 at the minimum, while our N12 RIIB−/− had an interval from D1Mit102 to D1Mit221 at the minimum, according to our analysis. The Fcr and SLAM loci are shown as shaded boxes at the top of the Upper panel or as thick lines above the map in the Lower panel. The Fcgr2b gene is boxed. When pertinent, we refer to our N28 RIIB−/− mice used in the present study as RIIB−/−SENDAI and those obtained or purchased from others as RIIB−/−TOKYO or RIIB−/−TACONIC, respectively, in order to distinguish the data in figures. (B) Survival curves for B6 (female, n =17), RIIB−/−SENDAI (female, n =30; male, n =35), SLAM129 (female, n =23; male, n =27), RIIB−/−SLAM129 (female, n =14; male, n =18), RIIB−/−TOKYO (female, n =7; male, n =4), and RIIB−/−TACONIC (female, n =3; male, n =3) mice. Mice of different lines were examined as to their survival until week 45. For comparison, survival curves for B6.lpr (female, n =17) and RIIB−/−lpr (female, n =28; male, n =12) from our previous study [16] are superimposed. ****Significantly different between female RIIB−/−TACONIC vs female RIIB−/−SENDAI (P <0.0001, Log-rank test).

Back to article page