Skip to main content

Table 1 Influence of diabetes induction by STZ and propolis supplementation to diabetic mice on the body weight and blood biochemical parameters

From: RETRACTED ARTICLE: Oral supplementation of diabetic mice with propolis restores the proliferation capacity and chemotaxis of B and T lymphocytes towards CCL21 and CXCL12 by modulating the lipid profile, the pro-inflammatory cytokine levels and oxidative stress

Days post STZ or vehicle injection

Groups

Body weight

Glucose

Insulin

ROS

IL-6

Cholesterol

Creatinine

WBC count

Lymphocyte count

(g)

(mg/dl)

(ng/ml)

(nmol/ml)

(pg/ml)

(mg/100 ml)

(dg/ml)

(x103/mm3)

(x103/mm3)

 3Day 3

Control

28.8 ± 1.9

103 ± 11

6.6 ± 0.48

33 ± 2.8

19 ± 2.4

37 ± 2.8

5.2 ± 0.44

15 ± 1.4

10.6 ± 1.2

Diabetic

29 ± 1.7

243 ± 21.4*

4 ± 0.35*

42 ± 4.6*

28.4 ± 3.1*

35.8 ± 3.2

5.4 ± 0.52

12.4 ± 1.1*

8 ± 0.68*

 Day 14

Control

30 ± 2.3

93 ± 8.2

6.4 ± 0.61

36 ± 3.4

18 ± 2.2

38.4 ± 2.4

4.8 ± 0.6

15.4 ± 1.6

10.4 ± 1.6

Diabetic

25 ± 2.1*

297 ± 24.6*

2.8 ± 0.3*

77 ± 5.8*

46 ± 4.2*

53 ± 4.2*

7.8 ± 0.62*

11 ± 1.2*

7.4 ± 0.8*

Weeks post propolisor vehicle treatment

Groups

 

 Week 1

Control

32 ± 2.4

109 ± 8.8

5.7 ± 0.5

27.1 ± 2.9

24.6 ± 2.4

33 ± 3.2

5.4 ± 0.5

15.8 ± 1.1

10.7 ± 1.1

Diabetic

24.6 ± 2.1*

374 ± 31.2*

3.3 ± 0.4*

79.8 ± 5.5*

44 ± 5.2*

62 ± 5.4*

7.9 ± 0.22*

12 ± 1.2*

7.8 ± 0.9*

Diab + Propolis

26.8 ± 2.4+

287 ± 24.8#+

4.2 ± 0.44+

44.1 ± 4.2#+

41 ± 4.2+

58.4 ± 5.8+

7.7 ± 0.3+

12.7 ± 1.6+

9.1 ± 4.1#+

 Week 2

Control

33.4 ± 3.6

96 ± 10.4

7.1 ± 0.75

39 ± 5.4

22 ± 2.7

39 ± 4.2

5.3 ± 0.75

15.4 ± 0.88

10.8 ± 1.2

Diabetic

23.6 ± 3.1*

411 ± 34.6*

2.6 ± 0.29*

98.6 ± 8.4*

66 ± 5.2*

79 ± 6.4*

8.2 ± 0.9*

11 ± 0.9*

7.6 ± 0.9 *

Diab + Propolis

28.4 ± 2.4#+

284 ± 26#+

3.9 ± 0.38#+

64 ± 4.8#+

34 ± 3.2#+

61.2 ± 5.5#+

5.9 ± 0.48#

12.4 ± 0.5#+

9.1 ± 0.92+

 Week 3

Control

34.2 ± 4.2

89 ± 11.4

5.8 ± 0.6

25.5 ± 3.2

26 ± 2.4

22.8 ± 3

4.8 ± 0.6

15.8 ± 1.22

10.9 ± 1.1

Diabetic

23 ± 2.8*

382 ± 31*

2.2 ± 0.2*

102 ± 9.2*

68.8 ± 3.2*

82 ± 8.4*

8.46 ± 0.8*

8.4 ± 0.8 *

7.1 ± 0.6 *

Diab + Propolis

28.8 ± 3.5#+

261 ± 25.5+

3.5 ± 0.34#+

51.6 ± 4.6#+

40 ± 3.8#+

42.3 ± 5.5#+

6.22 ± 0.44#+

13.1 ± 1.42#+

10.2 ± 0.65#+

 Week 4

Control

36.6 ± 2.9

119 ± 14

5.2 ± 0.45

31.5 ± 4.1

23 ± 3.4

19 ± 2.2

4.7 ± 0.42

15.4 ± 1.2

10.8 ± 1.4

Diabetic

22.84 ± 2.8*

368 ± 22*

1.8 ± 0.2*

144 ± 11.2*

79 ± 9*

59.6 ± 5.4*

8.8 ± 0.9*

8.5 ± 0.8*

6.7 ± 0.8*

Diab + Propolis

29.2 ± 2.6#+

244 ± 18#+

3.4 ± 0.35#+

48.6 ± 5.6#+

49 ± 6#+

37 ± 3.2#+

5.99 ± 0.37#+

14 ± 0.18#

10.1 ± 0.96#

  1. The body weight and blood biochemical parameters were measured in the 3 groups of mice throughout the experiment period. The pooled data for 3 mice from each group are expressed as the mean value for each parameter ± SEM
  2. *P < 0.05 for diabetic vs. control
  3. #P < 0.05 for diabetic + propolis vs. diabetic
  4. +P < 0.05 for diabetic + propolis versus control (ANOVA followed by Tukey’s post-test)
Back to article page

BMC Immunology

ISSN: 1471-2172

Contact us