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Table 1 Similarity of Mtb32A, Mtb39A, Mtb72F and M72 among selected Mycobacterium strains

From: Sequence conservation analysis and in silico human leukocyte antigen-peptide binding predictions for the Mtb72F and M72 tuberculosis candidate vaccine antigens

Lineagea

Strains

NCBI Accession number

Mtb39A

Mtb39A

Mtb32A

Mtb72F

M72

No. of aa changes

No. of aa/nt, position (pos)

% identity

Insertions

Deletions

Frameshifts

1

T17

PRJNA55273

3

   

99.23

94.37

96.79

96.65

 

T46

PRJNA55875

3

   

99.23b

-

-

-

 

T92

PRJNA55099

3

   

99.23

100

99.58

99.44

 

EAS054

PRJNA55133

117

1 nt, pos 811

 

1, pos 270-391

68.92

100

84.37

84.23

2

94_M4241A

PRJNA55095

0

   

100

100

100

99.86

 

210 (Mtb Beijing)

PRJNA42617

30

 

1 aa, pos 274

 

91.3

100

95.4

95.26

 

02_1987

PRJNA55097

1

   

99.74

100

99.86

99.72

 

T85

PRJNA55131

1

   

99.74

100

99.86

99.72

 

W-148 (Mtb. Beijing;MDR)

PRJNA182020

1

   

99.74

100

99.86

99.72

3

-

     

-

-

-

-

4

CDC1551

PRJNA57775

0

   

100

100

100

99.86

 

C

PRJNA54359

0

   

100b

-

-

-

 

F11

PRJNA58417

1

   

99.74

100

99.86

99.72

 

GM1503

PRJNA55271

-

-

-

-

-

100b

-

-

 

H37Rac

PRJNA58853

62

 

1 nt, pos 922

1, pos 309–391

82.28

100

90.56

90.42

 

Haarlem

PRJNA54453

0

   

100

100

100

99.86

 

KZN1435 (MDR)

PRJNA59069

0

   

100

100

100

99.86

 

98R604INHRIFEM

PRJNA55399

0

   

100

100

100

99.86

5

CPHL_A (M. africanum)

PRJNA55877

4

 

1 aa, pos 274

 

98.72

100

99.3

99.16

6

K85 (M. africanum)

PRJNA55879

3

2 aa, pos 162

1 aa, pos 274

 

98.48

100

99.17

99.03

n.d.

SUMu001

PRJNA51927

8

 

1 aa, pos 274

 

97.70

100

98.75

98.61

 

SUMu002

PRJNA51925

-

-

-

-

-

100b

-

-

 

SUMu003

PRJNA51931

2

   

99.49

100

99.72

99.58

 

SUMu004

PRJNA51933

2

 

1 aa, pos 274

 

99.23

100

99.58

99.44

 

SUMu005

PRJNA51935

2

 

1 aa, pos 274

 

99.23

100

99.58

99.44

 

SUMu006

PRJNA91937

2

   

99.49

100

99.72

99.58

 

SUMu008

PRJNA51941

-

-

-

-

-

100b

-

-

 

SUMu010

PRJNA51945

-

-

-

-

-

100b

-

-

 

KZN605 (XDR)

PRJNA54947

0

   

100

100

100

99.86

 

KZN4207

PRJNA83619

0

   

100

100

100

99.86

 

KZNR506 (XDR)

PRJNA47489

0

   

100

100

100

99.86

 

KZNV2475 (MDR)

PRJNA47491

1

   

99.74

100

99.86

99.72

 

UT205

PRJNA162183

0

   

100

100

100

99.86

 

BTB05-552

PRJNA51871

0

   

100

100

100

99.86

 

BTB05-559

PRJNA51873

0

   

100

100

100

99.86

 

S96-129

PRJNA51869

0

   

100

100

100

99.86

 

CCDC5079

PRJNA161943

1

   

99.74

100

99.86

99.72

 

CCDC5180

PRJNA161941

1

   

99.74

100

99.86

99.72

 

CTRI-2

PRJNA161997

0

   

100

100

100

99.86

 

CTRI-4 (XDR)

PRJNA43175

3

   

99.23

100

99.58

99.44

 

R1207 (MDR)

PRJNA46669

1

   

99.74

100

99.86

99.72

 

X122 (pre-XDR)

PRJNA46667

1

   

99.74

100

99.86

99.72

 

NA-A0008

PRJNA168604

6

   

98.47

100

99.58

99.44

 

NA-A0009

PRJNA168605

3

   

99.23

100

99.16

99.02

 

HN878

PRJNA46665

3

   

99.23

100

99.58

99.44

 

RGTB423

PRJNA162179

2

   

99.23

85.63

92.48

92.34

 

RGTB327

PRJNA157907

24

1 nt, pos 480

1 nt, pos 464

1, pos 139–155

93.91

100

96.67

96.53

    

2 nt, pos 951

1 nt, pos 468

1, pos 314–316

    
    

1 nt, pos 959

1 nt, pos 469

     
     

1 nt, pos 470

     
     

1 nt, pos 475

     

Affected Strains; no (%)

  

28 (67)

3 (7)

8 (19)

3 (7)

    

Average % identity

      

98.08

99.55

98.71

98.57

  1. aLineages as defined in ref. [30]: no. 1: The Philippines / rim of the Indian Ocean; no. 2: East Asia; no. 3: India / East Africa; no. 4: Europe / Americas; no. 5 and no. 6: West African 1 and 2, respectively. n.d., not defined. MDR, multiple drug-resistant; (pre-)XDR, (pre-)extensively drug-resistant. aa, amino acid(s); nt, nucleotide(s). bEvaluations not performed for Mtb72F/M72 as a complete sequence was only available for one of the two genes. % identity = (number of identical residues / length of alignment) x100, as calculated from multiple alignment comparisons. Mtb39A genome sequences were derived from complete genomes (chromosomes; highlighted in bold) or assembled partial genomes (scaffolds/contigs; normal font). cLaboratory strain H37Ra was used as reference