Fig. 6
One-cycle 5-FU combined with CIKs and PD-L1 antibodies improves therapeutic effect in vivo. a The chemo-immunotherapy schedule of CT26 tumor-bearing mice. Second day after 5-FU C1 last injection, 1 × 107 CIKs were injected into tumor and 200 μg αPD-L1 antibodies were injected intraperitoneally per mouse every 3 days for six times. b Tumor growth curve (data shown as the mean ± SEM) and c Kaplan-Meier survival analysis of control, 5-FU C4, immunotherapy (CIKs andαPD-L1) and chemo-immunotherapy. Five to six mice per group and the experiments replicated at least twice with similar results. Two-way ANOVA analysis for tumor volumes and log-rank test for survival comparisons