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Table 3 Correlation of plasma fetuin-A with inflammatory cytokines, chemokines and activation biomarkers in diabetic and non-diabetic individuals

From: Plasma fetuin-A/α2-HS-glycoprotein correlates negatively with inflammatory cytokines, chemokines and activation biomarkers in individuals with type-2 diabetes

Analyte

Diabetic

Non-diabetic

Pearson r

P

Pearson r

P

Cytokines

 IFN-α2

−0.44 (n = 52)

0.001**

0.04 (n = 56)

0.76

 IFN-γ

−0.41 (n = 49)

0.003**

0.05 (n = 66)

0.68

 IL-1α

−0.48 (n = 46)

0.001**

0.04 (n = 56)

0.76

 IL-1β

−0.57 (n = 46)

<0.0001***

−0.33 (n = 58)

0.01*

 IL-1RA

−0.46 (n = 52)

0.001**

0.24 (n = 63)

0.06

 IL-3

−0.30 (n = 24)

0.16

−0.79 (n = 14)

0.001**

 IL-4

−0.48 (n = 49)

0.001**

−0.01 (n = 60)

0.97

 IL-5

−0.0008 (n = 20)

0.99

0.58 (n = 19)

0.01*

 IL-6

−0.30 (n = 29)

0.12

0.08 (n = 33)

0.67

 IL-7

−0.52 (n = 51)

<0.0001***

−0.38 (n = 61)

0.003**

 IL-9

−0.47 (n = 18)

0.05*

−0.68 (n = 9)

0.04*

 IL-10

−0.18 (n = 40)

0.26

0.11 (n = 36)

0.52

 IL-12p40

−0.45 (n = 39)

0.004**

−0.23 (n = 36)

0.17

 IL-12p70

−0.41 (n = 49)

0.003**

−0.01 (n = 59)

0.92

 IL-13

−0.18 (n = 26)

0.39

0.56 (n = 20)

0.01*

 IL-15

−0.52 (n = 41)

0.0005***

−0.49 (n = 34)

0.003**

 IL-17A

−0.54 (n = 40)

0.0004***

−0.24 (n = 50)

0.09

 TNF-α

−0.66 (n = 50)

<0.0001***

−0.33 (n = 72)

0.04*

 TNF-β/ LT-α

−0.20 (n = 20)

0.46

0.62 (n = 16)

0.01*

Chemokines

 CCL-2/MCP-1

−0.69 (n = 53)

<0.0001***

−0.52 (n = 72)

<0.0001***

 CCL-3/MIP1-α

0.01 (n = 48)

0.93

0.30 (n = 53)

0.03*

 CCL-4/MIP1-β

−0.38 (n = 53)

0.005**

0.20 (n = 71)

0.10

 CCL-5/RANTES

0.04 (n = 48)

0.80

0.30 (n = 63)

0.02*

 CCL-7/MCP-3

0.16 (n = 10)

0.67

0.80 (n = 14)

<0.0001***

 CCL-11/Eotaxin-1

−0.42 (n = 53)

0.002**

−0.19 (n = 72)

0.10

 CCL-22/MDC

−0.47 (n = 53)

0.0003***

−0.32 (n = 72)

0.006**

 CX3CL-1/Fractalkine

−0.56 (n = 53)

<0.0001***

−0.30 (n = 70)

0.01*

 CXCL-8/IL-8

−0.52 (n = 47)

<0.0001***

0.24 (n = 52)

0.09

 CXCL-10/IP-10

−0.22 (n = 53)

0.12

−0.50 (n = 72)

<0.0001***

 Growth-related oncogene (GRO)

−0.69 (n = 53)

<0.0001***

−0.29 (n = 72)

0.01*

Adipokine

 Adiponectin

−0.14 (n = 48)

0.34

−0.01 (n = 63)

0.94

Growth Regulatory Factors

 EGF

−0.42 (n = 53)

0.002**

−0.03 (n = 70)

0.84

 EFF-2

−0.61 (n = 53)

<0.0001***

−0.29 (n = 72)

0.01*

 FLT-3 L

−0.32 (n = 20)

0.16

−0.08 (n = 7)

0.87

 G-CSF

−0.42 (n = 52)

0.002**

−0.02 (n = 72)

0.89

 GM-CSF

−0.45 (n = 30)

0.01*

0.82 (n = 44)

0.06

 TGF-α

0.03 (n = 21)

0.89

0.36 (n = 22)

0.10

 VEGF

−0.53 (n = 53)

<0.0001***

−0.29 (n = 71)

0.01*

Platelet Activation Marker

 sCD40L

−0.64 (n = 53)

<0.0001***

−0.48 (n = 72)

<0.0001***

  1. Note: Sample numbers <53 for diabetic and <72 for non-diabetic groups represent the missing data due to undetectable analyte levels in certain samples
  2. *significant; **highly significant; ***extremely significant