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Table 3 Capacity of splenic subset to induce a cytotoxic T cell response

From: Antigen presenting capacity of murine splenic myeloid cells

Peptide

No. APC from Actm-OVA mice used for priminga

Targets:

Concentration of peptide (uM) required to activate CTL for 50% lysis of targets

L-DC

Resi Mono

CD8+cDC

SIIN

90 K

0.1

0.1

1.0

9 K

10.0

> > 10

10.0

0.9 K

0

0

0

N6

90 K

0.001

0.001

0.001

9 K

0.01

1.0

0.01

0.9 K

0

0

0

G4

90 K

0

0

0

9 K

0

0

0

0.9 K

0

0

0

E1

90 K

0

0

0

9 K

0

0

0

0.9 K

0

0

0

  1. a The table summarises data obtained from the fluorescent target experiment described in Fig. 3. Mice were given sorted OT-I CD8+ T cells ahead of APC sorted from Act-mOVA mice. These included L-DC, Resident monocytes (Resi mono) and CD8+ cDC. Target cells were added after 6 days, and their lysis measured in terms of % cell recovery at 24 h