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Fig. 1 | BMC Immunology

Fig. 1

From: Fms-like tyrosine kinase-3 ligand increases resistance to burn wound infection through effects on plasmacytoid dendritic cells

Fig. 1

pDCs are essential for FL-mediated protection against a burn wound infection. a Timeline shows experimental protocols: Mice received burn injury on day 1 and FL treatment on days 2–5. Mice either received pDC depletion antibodies on days 1 and 2 (anti-pDC + FL) or on days 4 and 5 (FL + anti-pDC). IgG control mice received nonspecific IgG on days 1 and 2. Wounds were inoculated on day 5. Survival was monitored for 12 days following inoculation. *significantly different from FL, FL + anti-pDC, p ≤0.05, n = 9–17 mice per group. b Spleen and lymph nodes cells were stained and analyzed by FACS to confirm depletion of pDCs by anti-pDCA1 antibodies. Histograms are representative of staining in 3 mice/group and show PDCA-1 staining (light grey highlighted area) in CD45 (B220) + cells

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