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Fig. 5 | BMC Immunology

Fig. 5

From: Fms-like tyrosine kinase-3 ligand increases resistance to burn wound infection through effects on plasmacytoid dendritic cells

Fig. 5

pDCs are required, indirectly, for FL-mediated enhancement of neutrophil chemotaxis. a Neutrophils were harvested from burned mice treated with FL in the presence and absence of pDCs (IgG + FL, anti-pDC + FL) and migration towards fMLP was measured. *significantly different from other groups, p <0.05, n = 6–15. b PDCA-1+ pDCs were isolated from burned mice that had been treated in vivo with control LR or FL and were co-cultured overnight with neutrophils that had been harvested from burned, non-treated mice. Migration to fMLP was subsequently assessed. n = 5–15. c CD11c+ DCs were isolated from burned mice that had been depleted of pDCs or not at the start of FL treatment as in Fig. 1. Neutrophils were harvested from burned mice and co-cultured with DCs overnight prior to measurement of migration towards fMLP. *significantly different from all other groups, p <0.05, n = 4–6

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