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Table 4 Gene sets enriched in human monocytes stimulated with IL-10 immunodepleted plasma vs low LPS plasma

From: Transcriptomic data from two primary cell models stimulating human monocytes suggest inhibition of oxidative phosphorylation and mitochondrial function by N. meningitidis which is partially up-regulated by IL-10

Name of hallmark gene set

Descriptiona

FDR

Number of genes in the gene set

Founder gene setsb

TNF signaling via NfkB

Genes regulated by NF-kB in response to TNF

<0.001

200

120

Inflammatory response

Genes defining inflammatory response.

<0.001

200

120

Interferon gamma response

Genes up-regulated in response to IFNG

<0.001

200

82

Interferon alpha response

Genes up-regulated in response to alpha interferon proteins.

<0.001

97

82

IL2 STAT5 signaling

Genes up-regulated by STAT5 in response to IL2 stimulation.

<0.001

200

13

IL6 JAK-STAT3 signaling

Genes up-regulated by IL6 [via STAT3, e.g., during acute phase response.

<0.001

87

24

KRAS signaling up

Genes up-regulated by KRAS activation.

0.001

200

14

Epithelial mesenchymal transition

Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis

<0.001

200

 

Allograft rejection

Genes up-regulated during transplant rejection.

<0.001

200

190

MYC targets_v2

A subgroup of genes regulated by MYC

0.004

58

6

Complement

Genes encoding components of the complement system, which is part of the innate immune system.

0.004

200

71

Coagulation

Genes encoding components of blood coagulation system

0.005

138

71

Apoptosis

Genes mediating programmed cell death (apoptosis) by activation of caspases.

0.016

161

80

Estrogen response early

Genes defining early response to estrogen

0.018

200

 

KRAS signaling down

Genes down-regulated by KRAS activation.

0.029

200

16

Hypoxia

Genes up-regulated in response to low oxygen levels (hypoxia).

0.031

200

87

UV response up

Genes up-regulated in response to ultraviolet (UV) radiation

0.044

58

16

  1. aDescription of the gene sets were obtained from the Molecular Signatures Database
  2. bFounder gene sets constitute the original experiments associating the genes with specified functions or biological processes