Name of hallmark gene set | Descriptiona | FDR | Number of genes in the gene set | Founder gene setsb |
---|---|---|---|---|
TNF signaling via NfkB | Genes regulated by NF-kB in response to TNF | <0.001 | 200 | 120 |
Interferon gamma response | Genes up-regulated in response to IFNG | <0.001 | 200 | 82 |
Inflammatory response | Genes defining inflammatory response | <0.001 | 200 | 120 |
Interferon alpha response | Genes up-regulated in response to alpha interferon proteins | <0.001 | 97 | 82 |
IL6 JAK-STAT3 signaling | Genes up-regulated by IL6 [via STAT3, e.g., during acute phase response] | <0.001 | 87 | 24 |
IL2 STAT5 signaling | Genes up-regulated by STAT5 in response to IL2 stimulation | <0.001 | 200 | 13 |
MYC targets_v2 | A subgroup of genes regulated by MYC | <0.001 | 58 | 6 |
Epithelial mesenchymal transition | Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis | <0.001 | ||
Complement | Genes encoding components of the complement system | <0.001 | 200 | 71 |
Allograft rejection | Genes up-regulated during transplant rejection | <0.001 | 200 | 190 |
KRAS signaling up | Genes up-regulated by KRAS activation | 0.001 | 200 | 14 |
Estrogen response early | Genes defining early response to estrogen | 0.001 | ||
Coagulation | Genes encoding components of blood coagulation system | 0.001 | 138 | 71 |
UV response up | Genes up-regulated in response to ultraviolet (UV) radiation | 0.005 | 158 | 16 |
Hypoxia | Genes up-regulated in response to low oxygen levels (hypoxia) | 0.008 | 200 | 87 |
Apoptosis | Genes mediating programmed cell death (apoptosis) by activation of caspases | 0.013 | 161 | 80 |
Unfolded protein response | Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum | 0.036 | 113 | 22 |