Table 2 Bivariate and multivariate analysis of risk factors for immunological failure on ART/AIDs patients attending University of Gondar Referral Hospital 2017
Variables | Immunological failure | COR(95%CI) | AOR(95%CI) | P value | ||
|---|---|---|---|---|---|---|
Yes | No | |||||
Age | 18–29 | 13 (24.1%) | 41 (75.9%) | 2.58 (0.95–7.04) | 0.96 (0.25–3.66) | 0.955 |
30–39 | 18 (10.7%) | 151 (89.3%) | 0.97 (0.39–2.45) | 0.74 (.26–2.09) | 0.570 | |
40–49 | 18 (13.2%) | 118 (89.3%) | 1.23 (0.49–3.14) | 1.19 (0.43–3.34) | 0.731 | |
> = 50 | 7 (10.9%) | 57 (89.1%) |  |  | Ref | |
Educational status | Illiterate | 18 (14.9%) | 103 (85.1%) | 2.33 (0.65–8.34) | 2.05 (0.53–7.92) | 0.297 |
primary school | 17 (14.5%) | 100 (85.5%) | 2.27 (0.63–8.16) | 2.14 (0.57–0.14) | 0.265 | |
secondary school | 18 (12.7%) | 124 (87.3%) | 1.94 (0.54–6.91) | 1.55 (0.41–5.94) | 0.522 | |
Tertiary | 3 (7.0%) | 40 (93.0%) | Â | Â | Ref | |
Duration on ART in year | <=6 | 30 (18.5%) | 132 (81.5%) | 2.05 (1.16–3.62) | 2.07 (1.11–3.87) | 0.023* |
> 6 | 26(10%) | 235 (90)% |  |  | Ref | |
Initial regimen | D4T + 3TC+ EFV | 1 (3.4%) | 28 (96.6%) | 0.22 (0.03–1.77) | 0.29 (0.04–2.49) | 0.262 |
AZT +3TC + NVP | 20 (12.8%) | 136 (87.2%) | 0.89 (0.41–1.98) | 0.73 (0.28–1.92) | 0.529 | |
AZT + 3TC + EFV | 2 (6.7%) | 28 (93.3%) | 0.44 (0.09–2.09) | 0.46 (0.09–2.49) | 0.370 | |
TDF + 3TC + EFV | 10 (11.5%) | 77 (88.5%) | 0.79 (0.32–1.98) | 0.50 (0.16–1.59) | 0.239 | |
TDF + 3TC + NVP | 6(19.4%) | 25 (80.6%) | 1.46(0.49–4.37) | 0.99 (0.29–3.45) | 0.996 | |
D4T + 3TC + NVP | 2 (33.3%) | 4 (66.7%) | 3.04 (0.49–18.67) | 1.173 (0.18–7.49) | 0.866 | |
AZT+ 3TC + NVP(4c) | 4 (66.7%) | 2 (33.3%) | 12.18 (1.99–74.67) | 12.90 (1.17–142.67) | 0.051 | |
D4T + 3TC + NVP(4a) | 11 (14.1%) | 67 (85.9%) |  |  | Ref | |
Viral load | > = 20 | 33(28%) | 82(72%) | 4.987(2.775–8.963) | 5.19 (2.81–9.62) | 0.0001* |
<  20 | 23(7%) | 285(93%) |  |  | Ref | |