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Table 5 Bivariate vs multivariate analysis of treatment failure on adult HIV/AIDS patients attending University of Gondar Referral Hospital 2017

From: Prevalence and associated factors of treatment failure among HIV/AIDS patients on HAART attending University of Gondar Referral Hospital Northwest Ethiopia

Variables

Treatment failure

COR (95%CI)

AOR(95%CI)

P value

Yes

No

Age

18–29

19(35%)

35(65%)

2.93 (1.22–7.04)

1.59 (0.54–4.72)

0.398

30–39

31(18%)

138(82%)

1.21(0.56–2.64)

1.13 (0.49–2.61)

0.772

40–49

26(19%)

110(81%)

1.28(0.57–2.84)

1.31 (0.56–3.04)

0.530

> = 50

10(16%)

54(84%)

Ref

 

Ref

Educational status

No formal education

26(22%)

95(79%)

3.65 (1.05–12.75)

3.89(1.10–13.77)

.035*

primary school

26 (22%)

91(78%)

3.81 (1.09–13.32)

3.730(1.06–13.18)

.041*

secondary school

31 (22%)

111(78%)

3.72 (1.08–12.86)

2.93(0.83–10.38)

.096

Tertiary

3 (7%)

40(93%)

Ref

  

Duration of ART in yrs.

<  6

39(24%)

123(76%)

1.44 (0.89–2.33)

2.1 (1.12–3.81)

0.021*

6

47(18%)

214(82%)

  

Ref

Initial regimen

D4T + 3TC + NVP

18 (23%)

60(77%)

0.08 (0.01–0.71)

0.10 (0.01–1.06)

0.056

D4T + 3TC+ EFV

2 (7%)

27(93%)

0.02 (0.001–0.25)

0.03 (0.002–0.37)

0.007*

AZT +3TC + NVP

31 (20%)

125(80%)

0.06 (0.01–0.57)

0.07 (0.01–0.72)

0.025*

AZT + 3TC + EFV

4(13%)

26(87%)

0.04 (0.003–0.44)

0.05 (0.004–0.57)

0.016*

TDF + 3TC + EFV

14(16%)

73(84%)

0.05 (0.01–0.46)

0.04 (0.004–0.46)

0.009*

TDF + 3TC + NVP

9 (29%)

22(71%)

0.102 (0.01–1.045)

0.11 (0.01–1.25)

0.075

D4T + 3TC + NVP(4a) child regimen

4 (57%)

3(43%)

0.33 (0.02–4.736)

0.32 (0.02–4.76)

0.408

AZT + 3TC + NVP(4c) child regimen

4 (80%)

1(20%)

  

Ref

AZT +3TC + NVP

18(30%)

43(71%)

Ref

  
  1. Note: * Has significant association
  2. Those variables with in p value < 0.2 under bivariate analysis were included with in multivariate analysis
  3. COR crude odds ratio, AOR adjusted odds ratio, Ref reference, CI confidence interval, p significant value, D4T Stavudine, TDF TenofovirDisoproxilFumarate, AZT/ 3TC Zidovudine/Lamivudine, EFV Efavirenze, NVP Nevirapined, di Didanosine