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Table 1 Characteristics of 59 index patients with subnormal IgGSc and normal total IgGa

From: Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

Characteristic

Subnormal IgG1

Subnormal IgG3

Subnormal IgG1+ IgG3

All patients

n

13

33

13

59

Mean age, years ± SD

34 ± 13

45 ± 12

48 ± 13

44 ± 13

Men, % (n)

23.1 (3)

6.1 (2)

38.5 (5)

16.9 (10)

Diabetes, % (n)

0

6.1 (2)

15.1 (2)

6.8 (4)

Mean BMI, kg/m2 ± SD

27.3 ± 7.8

26.6 ± 5.7

30.8 ± 12.8

28.1 ± 8.2

Autoimmune condition(s), % (n)

23.1 (3)

42.4 (14)

30.8 (5)

37.3 (22)

Atopyb, % (n)

23.1 (3)

36.4 (12)

15.4 (2)

28.8 (17)

Other allergyc, % (n)

53.8 (7)

51.5 (17)

46.2 (6)

50.8 (30)

Mean IgA, mg/dL ± SD

154 ± 74

206 ± 106

196 ± 91

200 ± 95

Mean IgM, mg/dL ± SD

263 ± 86

120 ± 99

104 ± 75

117 ± 90

Median days between pre-, post-PPSV23 tests (range)

32 (27–47)

35 (19–129)

32 (19–158)

33 (19–158)

  1. aAbbreviations: Ig Immunoglobulin, BMI Body mass index, PPSV23 Polyvalent pneumococcal polysaccharide vaccination. IgG subclass levels were measured before IgG replacement therapy. Mean ± 2 SD was defined as reference ranges for all Ig measurements. Ig reference ranges are: total IgG 7.0–16.0 g/L (700–1600 mg/dL); IgG1 4.2–12.9 g/L (422–1292 mg/dL); IgG2 1.2–7.5 g/L (117–747 mg/dL); IgG3 0.4–1.3 g/L (41–129 mg/dL); IgG4 0–2.9 g/L (1–291 mg/dL); IgA 700–4000 mg/L (70–400 mg/dL); IgM 400–2300 mg/L (40–230 mg/dL). Subnormal Ig concentrations were defined as those below the corresponding reference limits
  2. bAllergic asthma, allergic rhinitis, or allergic dermatitis/eczema
  3. cUrticaria, angioedema, or anaphylaxis