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Table 2 Non-responders to pneumococcal serotypes in 59 index patients with subnormal IgGSc and normal total IgGa

From: Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

S. pneumoniae serotype

1

3

4

8

9

12

14

19

23

26

51

56

57

58

Subnormal IgG1, % NR

20

20

100

25

25

75

29

29

71

66

20

50

0

17

Subnormal IgG1, % R

0

0

0

0

0

0

0

17

17

0

0

0

0

0

Subnormal IgG3, % NR

55

50

85

50

85

100

56

40

72

64

40

71

0

64

Subnormal IgG3, % R

11

0

25

0

0

50

0

7

27

25

13

0

0

0

Subnormal IgG1 + IgG3, % NR

50

50

100

0

0

100

17

66

66

0

25

50

0

66

Subnormal IgG1 + IgG3, % R

20

0

33

0

0

75

0

14

14

0

0

33

0

0

  1. aAbbreviations: IgGSc IgG subclass(es), NR Non-responders, R Responders. We defined responders as patients who achieved protective levels of serotype-specific IgG post- polyvalent pneumococcal polysaccharide vaccination