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Fig. 4 | BMC Immunology

Fig. 4

From: Adaptive immune responses mediated age-related Plasmodium yoelii 17XL and 17XNL infections in 4 and 8-week-old BALB/c mice

Fig. 4

Flow cytometric analysis demonstrated PD-1 signaling promoted immune response in different species of Plasmodium-infected 4-week-old and 8-week-old BALB/c mice. Representative dot plots (upper-left panel) (a) and column diagram:upper-left panel, the proportion of CD4+PD-1+ cells in splenocytes (b) and absolute cell number (c) of CD4+PD-1+ cells in 4-week-old and 8-week-old BALB/c mice after P.y17XNL infection are displayed. Representative dot plots (lower-left panel) (d) and column diagram:lower-left panel, the proportion of CD4+PD-1+ cells in splenocytes (e) and absolute cell number) (f) of CD4+PD-1+ cells in 4-week-old and 8-week-old BALB/c mice after P.y17XL infection are displayed. Results are presented as arithmetic mean of 9 mice each group ± SE. Single asterisk (*) and double asterisks (**) indicate p < 0.05 and p < 0.01, respectively, as compared with control mice. A single pound sign (#) and double pound sign (##) indicate p < 0.05 and p < 0.01, respectively, as compared with 8-week-old mice. Normal control group: 0 day group

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