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Table 1 Significant GAGE pathways

From: Predicting the allergenicity of legume proteins using a PBMC gene expression assay

Treatment Soybean (50 μg/mL) White bean (50 μg/mL) Soybean (50 μg/mL)
Control White bean (50 μg/mL) control control
Cytokine-cytokine receptor interaction p < 0.01 p < 0.01
Osteoclast differentiation p < 0.01 p < 0.01
Neuroactive ligand-receptor interaction p < 0.01 p < 0.01
Hematopoietic cell lineage p < 0.01 p < 0.01
Rap1 signalling pathway p < 0.01 p < 0.01
Chemokine signalling pathway p < 0.01 p < 0.01
PI3K-Akt signalling pathway p < 0.01 p < 0.01
Complement and coagulation cascades p < 0.01
Jak-STAT signalling pathway p < 0.01 p < 0.01
IL-17 signalling pathway p < 0.01 p < 0.01
PPAR signalling pathway p < 0.01 p < 0.01
Ovarian steroidogenesis p < 0.01 p < 0.01
Focal adhesion p < 0.01
Protein digestion and absorption p < 0.01
  1. Differences between the weakly allergenic 7S globulin from white bean and the strongly allergenic 7S globulin from soybean for three comparisons (soybean 50 μg/mL versus white bean 50 μg/mL, white bean 50 μg/mL versus control and soybean 50 μg/mL versus control) are shown. Significance per pathway and comparison is indicated by p < 0.01 (unadjusted p-value)