Skip to main content
Fig. 1 | BMC Immunology

Fig. 1

From: Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation

Fig. 1

Quantitation of Bb binding and uptake by WT and MyD88−/− BMDMs. a Confocal 40x images of WT and MyD88−/− BMDMs after 6 h of stimulation with Bb at MOI 10:1, highlighting bound (yellow arrows) and internalized (white arrows) spirochetes. Green is Bb, red is actin and blue is cell nucleus. b-c Quantitation of bound spirochetes to WT (grey bars) or MyD88−/− (dark red bars) BMDMs after 1, 4 or 6 h of stimulation at a MOI of 10:1 (b) or 100:1 (c). d-e Quantitation of internalized spirochetes to WT (black bars) or MyD88−/− (red bars) BMDMs after 1, 4 or 6 h of stimulation at MOI 10:1 (d) or 100:1 (e). n = 3–5 mouse BMDM experiments per genotype *p-value< 0.05, **p-value< 0.01, ***p-value< 0.001, NS = not significant

Back to article page