Skip to main content
Fig. 2 | BMC Immunology

Fig. 2

From: TREM2 promotes natural killer cell development in CD3CD122+NK1.1+ pNK cells

Fig. 2

Blockade of TREM2 signaling reduces the NK cell population in vivo. a WT mice were injected with 100 μg of TREM2-Ig or hu-Ig (control) twice per week for 4 weeks intraperitoneally, then the expression of NK cell-specific receptors in the spleen, BM, and liver cells of WT mice was analyzed using flow cytometry. a The percentage (top panel) and absolute number (bottom panel) of NK1.1+ cells from the spleen (N = 4), BM (N = 6), and liver (N = 5) of mice as shown in Fig. 1a. Each symbol represents an individual mouse; horizontal lines indicate the mean. **P < 0.01 by unpaired Student’s t-test. b Graphs of absolute cell number of NK cells expressing each NK cell receptor in the spleen (left panel), BM (middle panel), and liver (right panel) of mice treated with hu-Ig (open bar) or TREM2-Ig (solid bar). For each population, the absolute number determined by calculation from flow cytometry profiles. Data are shown as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01 and ***P < 0.001 by based on two-way ANOVA analysis with Bonferroni posthoc test

Back to article page