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Fig. 2 | BMC Immunology

Fig. 2

From: Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis

Fig. 2

Glycyrrhizin suppresses cell proliferation and the expression of inflammatory factors in HaCaT cells. a The CCK-8 results indicate that IL-17A promoted the proliferation of HaCaT cells, while glycyrrhizin inhibited the proliferation of HaCaT cells. b-d After treatment with IL-17A for 48 h, the expression of IL-6 was substantially higher in the lysate and supernatant of HaCaT cells, while glycyrrhizin could reverse the promotion of IL-6 induced by IL-17A (b). Besides, glycyrrhizin has the same regulation of CCL20 (c) and TNF-α (d) as IL-6. NOTES: Data are presented as mean ± SD (n = 3). *P < 0.05, **P < 0.01 and ***P < 0.001 vs control; Con represents wild type HaCaT cells; GA represents glycyrrhizin; IL-17 represents IL-17A; #P < 0.05 vs IL-17A lysate or supernatant group

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