Table 2 All statistically significant differentially expressed neutrophil genes comparing T2D (N = 11) vs. healthy (N = 7) subjects

SLC9A4

solute carrier family 9 member A4

pH Regulation / Signaling

−5.42

7.46E-08

0.001

NECTIN2

Nectin cell adhesion molecule 2

Immune

−3.77

2.23E-07

0.002

PLPP3

phospholipid phosphatase 3

Lipids / Inflammation

−5.37

3.38E-07

0.002

C3

complement C3

Inflammation / Immune

−3.61

7.92E-07

0.003

IRAK2

interleukin-1 receptor-associated kinase 2

Inflammation / Immune

−4.01

8.93E-07

0.003

KCNH4

potassium voltage-gated channel subfamily H member 4

Lipids / Insulin

−4.41

9.15E-07

0.003

C1orf61

chromosome 1 open reading frame 61

Transcription

−4.71

2.08E-06

0.005

CCRL2

C-C motif chemokine receptor like 2

Inflammation / Immune

−3.37

2.61E-06

0.005

GNPDA1

glucosamine-6-phosphate deaminase 1

Glucose Metabolism

−2.95

2.70E-06

0.005

CLIC4

chloride intracellular channel 4

Cell Processes

−3.54

3.76E-06

0.007

GPR84

G protein-coupled receptor 84

Inflammation / Immune

−3.41

4.09E-06

0.007

PLAU

plasminogen activator, urokinase

Immune / Blood

−3.83

7.31E-06

0.01

SLC43A3

solute carrier family 43 member 3

Transmembrane Transport

−3.34

1.04E-05

0.01

RHOV

ras homolog family member V

Cell Processes / Signaling

−4.11

1.14E-05

0.01

SGPP2

sphingosine-1-phosphate phosphatase 2

Inflammation / Immune

−3.42

1.19E-05

0.01

TNFAIP6

TNF alpha induced protein 6

Inflammation / Immune

−3.01

1.69E-05

0.02

C15orf48

chromosome 15 open reading frame 48

Immune

−4.01

1.84E-05

0.02

TLCD2

TLC domain containing 2

Lipids

−1.60

2.28E-05

0.02

GTSCR1

Gilles de la Tourette syndrome chromosome region, candidate 1

-*

3.71

2.39E-05

0.02

SLC25A13

solute carrier family 25 member 13

Mitochondrial / Cell Processes

−2.32

2.57E-05

0.02

RP11-1193F23.1

–

–

−2.68

2.68E-05

0.02

SPHK1

sphingosine kinase 1

Lipids / Inflammation

−3.33

2.73E-05

0.02

DNAH17

dynein axonemal heavy chain 17

Motility (Sperm)

−2.94

2.79E-05

0.02

SPATC1

spermatogenesis and centriole associated 1

–

−3.09

2.96E-05

0.02

RALGDS

ral guanine nucleotide dissociation stimulator

Cell Processes

−2.69

3.01E-05

0.02

VEGFA

vascular endothelial growth factor A

Cell Growth / Angiogenesis / Lipids

−2.01

3.05E-05

0.02

HTRA3

HtrA serine peptidase 3

Signaling / Binding

−3.81

3.37E-05

0.02

CTB-114C7.4

–

–

−2.36

3.48E-05

0.02

MFSD2A

major facilitator superfamily domain containing 2A

Lipids / Transmembrane Transport (Brain)

−2.96

3.88E-05

0.02

AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

Signaling (Brain)

−2.61

3.90E-05

0.02

PNPLA1

patatin like phospholipase domain containing 1

Lipids

−2.53

4.15E-05

0.02

ABCG1

ATP binding cassette subfamily G member 1

Inflammation / Immune / Lipids

−1.45

4.28E-05

0.02

PTGES

prostaglandin E synthase

Inflammation / Lipids

−3.13

4.46E-05

0.02

TBC1D30

TBC1 domain family member 30

Transport / GTPase

−2.14

4.55E-05

0.02

GPR4

G protein-coupled receptor 4

Angiogenesis / Lipids

−3.48

5.35E-05

0.03

CD300LD

CD300 molecule like family member d

Immune

−2.41

5.97E-05

0.03

KLHDC8B

kelch domain containing 8B

Cell Processes / Mitosis

−2.25

7.90E-05

0.04

ANKRD33B

ankyrin repeat domain 33B

–

−2.05

8.21E-05

0.04

LPCAT1

lysophosphatidylcholine acyltransferase 1

Lipids

−1.86

8.31E-05

0.04

RP1-239B22.5

–

–

−3.87

9.27E-05

0.04

CTA-126B4.7

uncharacterized LOC101927344

–

−2.70

1.06E-04

0.05

TRAF3

TNF receptor associated factor 3

Immune

−2.01

1.22E-04

0.05

LAMB3

laminin subunit beta 3

Cell Processes

−3.02

1.23E-04

0.05

TTPAL

alpha tocopherol transfer protein like

–

−2.13

1.25E-04

0.05

TMEM231

transmembrane protein 231

Ciliogenesis

−2.28

1.28E-04

0.05

AZIN1

antizyme inhibitor 1

Cell Growth / Homeostasis

−1.90

1.30E-04

0.05

MARCH3

membrane associated ring-CH-type finger 3

Endosomal Transport

−2.31

1.38E-04

0.05

LIMS1

LIM zinc finger domain containing 1

Cytoskeleton / Signaling

−2.14

1.38E-04

0.05

NCR3LG1

natural killer cell cytotoxicity receptor 3 ligand 1

Immune

−3.55

1.41E-04

0.05

SQSTM1

sequestosome 1

Immune / Signaling

−1.78

1.42E-04

0.05