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Fig. 4 | BMC Immunology

Fig. 4

From: Pharmacological activation of rev-erbα suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss

Fig. 4

SR9009 alleviated the embryo resorption rate and alleviated the M1/M2-like polarization changes of F4/80+ dMφs in LPS-induced abortion model. A, Representative pictures of fetus loss in the mice abortion model with or without SR9009 treatment. Red arrows referred to the position of embryo resorption. B, Quantitative of resorption rate, total implantation site, normally developing implantation site and resorbed implantation site of mice abortion model with or without SR9009 treatment (n = 5 mice). C-D, Representative and quantitative flow cytometric analysis of the expression of M1 and M2 markers in F4/80+ dMφs from mice abortion model with or without SR9009 treatment (n = 3 mice). Data showed mean ± SEM of independent experiments, *P < 0.05, **P < 0.01, ***P < 0.001, compared to mice without LPS and SR9009 treatment; #P < 0.05, ##P < 0.01, ###P < 0.001, compared to mice with LPS treatment

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