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Table 2 Humoral responses against pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (PRN) (mean ± SEM)

From: Immunogenicity of a new enhanced tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccine against Bordetella pertussis in a murine model

 

Negative control

Positive control

GC3111

Enhanced GC3111

Anti-PT IgG (U/mL)

 Naïve (N = 5)

0.86 ± 0.17

0.55 ± 0.16

0.66 ± 0.16

0.82 ± 0.31

 1w before booster vaccination (n = 6)

0

9,804.25 ± 1,061.82

8,102.17 ± 1,002.83

10,608.92 ± 2,022.17

 2w after booster vaccination (N = 10)

92.20 ± 63.98

15,457.80 ± 1,781.44

11,734.00 ± 886.59

16,580.25 ± 1,663.38

 4w after booster vaccination (N = 10)

0

22,270.00 ± 3,286.30

19,936.00 ± 2,972.66

19,203.90 ± 3,494.35

Anti-FHA IgG (U/mL)

 Naïve (N = 5)

0.01

0

0

0.02 ± 0.01

 1w before booster vaccination (N = 6)

0.88 ± 0.22

51.41 ± 9.98

48.39 ± 11.00

40.74 ± 7.85

 2w after booster vaccination (N = 10)

0

117.70 ± 17.95

73.10 ± 15.04

93.90 ± 16.80

 4w after booster vaccination (N = 10)

7.50 ± 3.84

78.00 ± 8.79

60.50 ± 3.45

62.00 ± 6.35

Anti-PRN IgG (U/mL)

 Naïve (N = 5)

0

0

0

0

 1w before booster vaccination (N = 6)

2.88 ± 2.80

510.42 ± 42.25

436.08 ± 38.92

456.75 ± 52.19

 2w after booster vaccination (N = 10)

96.40 ± 96.40

2,181.00 ± 225.35

2,629.10 ± 272.59

2,686.10 ± 320.84

 4w after booster vaccination (N = 10)

18.90 ± 18.90

1,491.50 ± 127.52

2,101.40 ± 73.77

1,918.10 ± 237.37

  1. SEM = standard errors of the means