| Negative control | Positive control | GC3111 | Enhanced GC3111 |
---|---|---|---|---|
Anti-PT IgG (U/mL) | ||||
 Naïve (N = 5) | 0.86 ± 0.17 | 0.55 ± 0.16 | 0.66 ± 0.16 | 0.82 ± 0.31 |
 1w before booster vaccination (n = 6) | 0 | 9,804.25 ± 1,061.82 | 8,102.17 ± 1,002.83 | 10,608.92 ± 2,022.17 |
 2w after booster vaccination (N = 10) | 92.20 ± 63.98 | 15,457.80 ± 1,781.44 | 11,734.00 ± 886.59 | 16,580.25 ± 1,663.38 |
 4w after booster vaccination (N = 10) | 0 | 22,270.00 ± 3,286.30 | 19,936.00 ± 2,972.66 | 19,203.90 ± 3,494.35 |
Anti-FHA IgG (U/mL) | ||||
 Naïve (N = 5) | 0.01 | 0 | 0 | 0.02 ± 0.01 |
 1w before booster vaccination (N = 6) | 0.88 ± 0.22 | 51.41 ± 9.98 | 48.39 ± 11.00 | 40.74 ± 7.85 |
 2w after booster vaccination (N = 10) | 0 | 117.70 ± 17.95 | 73.10 ± 15.04 | 93.90 ± 16.80 |
 4w after booster vaccination (N = 10) | 7.50 ± 3.84 | 78.00 ± 8.79 | 60.50 ± 3.45 | 62.00 ± 6.35 |
Anti-PRN IgG (U/mL) | ||||
 Naïve (N = 5) | 0 | 0 | 0 | 0 |
 1w before booster vaccination (N = 6) | 2.88 ± 2.80 | 510.42 ± 42.25 | 436.08 ± 38.92 | 456.75 ± 52.19 |
 2w after booster vaccination (N = 10) | 96.40 ± 96.40 | 2,181.00 ± 225.35 | 2,629.10 ± 272.59 | 2,686.10 ± 320.84 |
 4w after booster vaccination (N = 10) | 18.90 ± 18.90 | 1,491.50 ± 127.52 | 2,101.40 ± 73.77 | 1,918.10 ± 237.37 |