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Table 4 Comparison of clinical characteristics of RA-ILD patients with different levels of sPD-1

From: Soluble programmed death molecule 1 (sPD-1) as a predictor of interstitial lung disease in rheumatoid arthritis

 

sPD-1

P value

High-level group

n = 34

Low-level group

n = 24

Age (years, mean ± SD)

66.0 ± 9.7

65.2 ± 9.0

0.689

Female, (n, %)

22 (64.7)

15 (62.5)

0.863

Disease duration (months), median, IQR

60 (12, 141)

60 (36, 120)

0.548

Smoking history, (n, %)

9 (26.5)

5 (20.8)

0.621

RF titer (IU/ml), mean ± SD

538.8 ± 1151.9

542.8 ± 928.1

0.989

Anti-CCP positive, mean ± SD

32 (94.1)

22 (91.7)

0.717

ESR (mm/h), mean ± SD

48.9 ± 34.1

53.5 ± 31.4

0.60

CRP (mg/dl), mean ± SD

36.0 ± 51.1

29.3 ± 33.9

0.549

DAS28-ESR, mean ± SD

4.5 ± 1.3

5.2 ± 1.7

0.105

HRCT score, mean ± SD

6.2 ± 3.1

5.3 ± 3.7

0.319

CT-UIP (n, %)

23(67.6)

11(45.8)

0.096

FVC%, mean ± SD

82.5 ± 20.1

94.8 ± 15.2

0.022*

DLCO%, mean ± SD

58.4 ± 15.5

66.2 ± 20.6

0.201

Cough (n, %)

21 (61.8)

10 (41.7)

0.131

Dyspnea (n, %)

6 (17.6)

3 (12.5)

0.722

Chest tightness (n, %)

14 (41.2)

6 (25.0)

0.202

Use of GCs (n, %)

23 (67.6)

21 (87.5)

0.121

Use of MTX (n, %)

6 (17.6)

3 (12.5)

0.722

  1. sPD-1 soluble programmed death molecule-1, ESR erythrocyte sedimentation rate, CRP C-reactive protein, DAS28 disease activity score using 28 joint counts, HRCT high resolution computerized tomography, UIP usual interstitial pneumonitis, RF rheumatoid factor, anti-CCP anticitrullinated peptide antibody, MTX methotrexate, GCs glucocorticoids (in prednisolone equivalent)