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Table 1 Details of the MDR and MRP-derived peptides and the MDP-specific T cells

From: Multidrug-resistance proteins are weak tumor associated antigens for colorectal carcinoma

Protein

Accession Number1

Name

Peptide2

SYFPEITHI Score3

Fluorescence Index4

INFγ

ELISpot5

Cytotoxicity

Test6

Influenza Matrix Protein

AAA43682

MP

57-GILGFVFTL

30

0,80

  

Growth Regulated Protein P68

226021

P68

128-YLLPAIVHI

30

0,93

  

MDR-1

AF016535

MDP01

686-ALDESIPPV

29

2,07

0,61

 
  

MDP02

218-ILAISPVLGL

30

0,17

0,27

 
  

MDP03

858-LLLLAIVPII

27

0,96

0,17

 
  

MDP04

551-LLLDEATSAL

26

0,64

0,30

 
  

MDP05

850-FIYGWQLTLL

26

0,22

9,94

89,7

MDR-3

NM_018849

MDP04

551-LLLDEATSAL

26

0,64

0,30

 
  

MDP05

850-FIYGWQLTLL

26

0,22

9,94

89,7

  

MDP06

467-YLREIIGVV

28

0,13

0,60

 
  

MDP07

833-ALIAQNIANL

30

0,25

0,99

44,2

  

MDP08

860-LLAVVPIIAV

29

0,64

1,75

62,9

MRP-1

L05628

MDP09

1224-SLSAGLVGL

31

0,04

0,37

 
  

MDP10

452-ILALYLLWL

30

0,17

0,34

 
  

MDP11

745-ALLPDLEIL

30

0,61

0,52

88,2

  

MDP12

1109-LLATPIAAI

30

0,39

0,80

 
  

MDP13

118-LLATFLIQL

29

0,42

0,02

 
  

MDP14

508-ILNGIKVLKL

32

0,27

0,08

 
  

MDP15

461-NLGPSVLAGV

29

0,49

0,42

65,8

  

MDP16

466-VLAGVAVMVL

29

0,24

0,06

 

MRP-2

NM_000392

MDP17

661-IMAGQLVAV

31

0,42

0,04

 
  

MDP18

783-LLDDPLSAV

29

1,55

1,57

80,2

  

MDP19

42-LLAPWQLLHV

31

0,21

1,41

29,4

  

MDP20

77-ILAAIELALV

30

0,50

0,55

 
  

MDP21

782-YLLDDPLSAV

30

1,49

0,77

 

MRP-3

AF104943

MDP14

508-ILNGIKVLKL

32

0,27

0,08

 
  

MDP15

461-NLGPSVLAGV

29

0,49

0,42

65,8

  

MDP18

783-LLDDPLSAV

29

1,55

1,57

80,2

  

MDP22

1220-SLNPGLVGL

34

0,64

1,07

 
  

MDP23

1020-ILQGFLVML

31

1,33

0,47

 
  

MDP24

1082-VLAPVILML

30

1,98

0,50

 
  

MDP25

422-DLAPFLNLL

29

0,50

0,06

 
  

MDP26

1115-ILPLAVLYTL

29

0,23

0,18

 

MRP-5

XM_002914

MDP27

304-AILGMIYNV

29

1,09

0,37

 
  

MDP28

784-LLLGETPPV

29

1,35

0,67

24,9

  

MDP29

296-LLAGGPVVAI

31

0,23

5,07

97,04

  

MDP30

1237-GMALFRLVEL

29

0,26

0,05

 
  1. 1 Protein or nucleotide accession numbers are indicated
  2. 2 Position of the start amino acid in the protein is indicated
  3. 3 Predicted binding scores to HLA-A2.1 using computer assisted analysis
  4. 4 (Mean fluorescence with peptide-mean fluorescence without peptide)/(mean fluorescence without peptide)
  5. 5 Percentage of cells in the MDP-specific T cell bulk cultures secreting IFN-γ upon stimulation with peptide-loaded T2 cells (maximum values observed over time of stimulation)
  6. 6 Lysis of MDP-loaded T2 cells in % at an effector to target cell ratio of 100:1
  7. Results are representative of at least two experiments.
  8. MDPs derived from more than one protein are listed twice with lighter shading when listed the second time.
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BMC Immunology

ISSN: 1471-2172

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