Neonatal infections in Saudi Arabia: association with C-reactive protein, CRP -286 (C>T>A) gene polymorphism and IgG antibodies

Table 7 Logistic regression analysis of CRP levels in ng/ml in relation to higher antibodies isotype in the combined study populations

Antibody isotopes	Categorized CRP levels	OR (95% CI)	P value
IgG	Less than 0.239	1.00
	Within 0.240 to 1.300	0.57 (0.29–1.12)	0.102
	Higher than 1.301	1.310 (0.66–2.57)	0.434
IgG1	Less than 0.239	1.00
	Within 0.240 to 1.300	1.30 (0.66–2.55)	0.444
	Higher than 1.301	1.46 (0.75–2.87′)	0.268
IgG2	Less than 0.239	1.00
	Within 0.240 to 1.300	0.44 (0.35–3.05)	0.202
	Higher than 1.301	0.74 (0.35–1.06)	0.034
IgG3	Less than 0.239	1.00
	Within 0.240 to 1.300	1.23 (0.63–2.40)	0.552
	Higher than 1.301	1.55 (0.79–3.047)	0.201
IgG4	Less than 0.239	1.00
	Within 0.240 to 1.300	1.23 (0.63–2.40)	0.548
	Higher than 1.301	0.86 (0.44–1.69)	0.862

To quantify the independent relationship between antibodies isotype (were ranked into two groups of their distributions), and CRP levels. The CRP levels were grouped into third of their distributions and comparisons were made with last categorized level (higher concentration) as reference value. OR represent odds ratios while CI represents confidence intervals. Lower concentration of antibodies was assigned 0; higher concentration of antibodies was assigned 1 in the logistic regression analysis. OR above 1 represented value associated to higher concentration of antibodies while less than 1 value represented lower concentration of antibodies.

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