Figure 2

Immunophenotypes of CD25⁺ or CD25^high CD4⁺ T cells in Control, HTLV, or HAM/TSP subjects. Dot plots depict the gating strategies for CD25⁺ and CD25^high cells (A); CD127^low (B); and CTLA-4 expression (C) are shown. The gates for CD25⁺ and CD4⁺CD25^high T cells were set based on the expression level of CD25 on CD4^- T cells, where the pattern of CD25 expression is more distinct. Accordingly, CD4⁺CD25^high T cells were defined as those expressing CD25 at a level higher than the bulk CD4^-CD25⁺ population. For D-K, individual results are represented in symbols, and the line represents the mean. (D) % CD4⁺CD25⁺T cells; (E) % CD4⁺CD25^high T cells; (F) % CD4⁺CD25⁺CTLA-4⁺ T cells; (G) % of CD4⁺CD25^highCTLA-4⁺ T cells; (H) % CD4⁺CD25⁺CD127^low T cells; (I) % CD4⁺CD25^highCD127^low T cells; (J) % CD4⁺CD25^highGITR⁺ T cells; and (K) % CD4⁺CD25^highGITR⁺ T cells.