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Fig. 1 | BMC Immunology

Fig. 1

From: Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study

Fig. 1

The concentration-dependent effect of dexamethasone and clarithromycin on the production of interleukin (IL)-8, IL-10 and Clara cell 10-kD protein (CC10). Both of dexamethasone and clarithromycin demonstrated a significant concentration-dependent effect on the protein production of (a-c) IL-8 and (d-f) IL-10 and (g-i) mRNA production of CC10 from sinonasal mucosa from different phenotypic chronic rhinosinusitis after 24-h culture (P < 0.05). Maximal effect was seen at a concentration of 10−5 mol/L. An equivalent volume of methanol solution was used as control for dexamethasone and clarithromycin. CRSsNP, chronic rhinosinusitis without nasal polyps; Non-Eos CRSwNP, non-eosinophilic chronic rhinosinusitis with nasal polyps; Eos CRSwNP, eosinophilic chronic rhinosinusitis with nasal polyps; CLA, clarithromycin; DEX, dexamethasone. n = 5 for CRSsNP, and Eos and Non-Eos CRSwNP group

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BMC Immunology

ISSN: 1471-2172

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