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Fig. 10 | BMC Immunology

Fig. 10

From: Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study

Fig. 10

The effect of dexamethasone and clarithromycin on the expression or production of tissue remodeling factors. The protein levels of (a) vascular endothelial growth factor (VEGF), (b) basic fibroblast growth factor (FGF-basic) and (c) platelet derived growth factor-BB (PDGF-BB) in culture supernatants, and the mRNA relative expression levels of (d) epidermal growth factor (EGF), (e) matrix metalloproteinases 9 (MMP9) and (f) transforming growth factor-β1 (TGF-β1) in sinonasal mucosa, from different phenotypic chronic rhinosinusitis after 24-h culture with 10−5 mol/L of dexamethasone or clarithromycin. An equivalent volume of methanol solution was used as control for dexamethasone and clarithromycin. CRSsNP, chronic rhinosinusitis without nasal polyps; Non-Eos CRSwNP, non-eosinophilic chronic rhinosinusitis with nasal polyps; Eos CRSwNP, eosinophilic chronic rhinosinusitis with nasal polyps; CLA, clarithromycin; CON, control; DEX, dexamethasone. n = 5 for CRSsNP group; n = 6 for Eos and Non-Eos CRSwNP group. *P < 0.05

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BMC Immunology

ISSN: 1471-2172

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