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Fig. 3 | BMC Immunology

Fig. 3

From: Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study

Fig. 3

Glucocorticoid receptor antagonist, mifepristone, diminishes the effect of dexamethasone. Mifepristone (10−5 mol/L) antagonized the effect of dexamethasone (10−5 mol/L) on the reduction of (a) IL-8 protein, and the promotion of (b) IL-10 protein and (c) Clara cell 10-kD protein (CC10) mRNA production in the sinonasal mucosa from different phenotypic chronic rhinosinusitis after 24-h culture. An equivalent volume of methanol solution was used as control for dexamethasone and clarithromycin. CRSsNP, chronic rhinosinusitis without nasal polyps; Non-Eos CRSwNP, non-eosinophilic chronic rhinosinusitis with nasal polyps; Eos CRSwNP, eosinophilic chronic rhinosinusitis with nasal polyps; CLA, clarithromycin; DEX, dexamethasone; MIF, mifepristone. n = 5 for CRSsNP, and Eos and Non-Eos CRSwNP group. *P < 0.05

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BMC Immunology

ISSN: 1471-2172

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