Skip to main content
Fig. 9 | BMC Immunology

Fig. 9

From: Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study

Fig. 9

The effect of dexamethasone and clarithromycin on the expression of pattern recognition receptors. The mRNA expression levels of (a) melanoma differentiation-associated gene-5 (MDA-5), (b) toll like receptor (TLR)2, (c) TLR3, (d) TLR4, and (e) TLR9 in the sinonasal mucosa from different phenotypic chronic rhinosinusitis after 24-h culture with 10−5 mol/L of dexamethasone or clarithromycin. An equivalent volume of methanol solution was used as control for dexamethasone and clarithromycin. CRSsNP, chronic rhinosinusitis without nasal polyps; Non-Eos CRSwNP, non-eosinophilic chronic rhinosinusitis with nasal polyps; Eos CRSwNP, eosinophilic chronic rhinosinusitis with nasal polyps; CLA, clarithromycin; CON, control; DEX, dexamethasone. n = 5 for CRSsNP group; n = 6 for Eos and Non-Eos CRSwNP group. *P < 0.05

Back to article page

BMC Immunology

ISSN: 1471-2172

Contact us